New microtubule-inhibiting anticancer agents

被引：56

作者：

Chen, Si-Meng ^{[1
]}

Meng, Ling-Hua ^{[1
]}

Ding, Jian ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China

来源：

EXPERT OPINION ON INVESTIGATIONAL DRUGS | 2010年 / 19卷 / 03期

基金：

中国国家自然科学基金;

关键词：

III BETA-TUBULIN; CELL LUNG-CANCER; NEW-GENERATION TAXOIDS; RESISTANT TUMOR-CELLS; PSEUDOLARIX ACID-B; STABILIZING AGENTS; BIOLOGICAL EVALUATION; IN-VIVO; COLCHICINE SITE; TYROSINE-LIGASE;

D O I：

10.1517/13543780903571631

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

What the reader will gain: This review mainly describes new microtubule-targeting anticancer agents that have been discovered (especially over the past 2 years), with emphasis on their diversity of structures and distinct modes ofaction. Areas covered in this review: Data were obtained exclusively from public sources, including journals and scientific meeting abstracts, up to September 2009. Take home message: A number of new agents have been discovered, and some have entered clinical trials. Even though most of these agents stabilize or destabilize tubulin via binding on the recognized tubulin binding sites, a few compounds bind to tubulin on undefined sites or interrupt microtubule in diverse ways. Moreover, some agents target microtubule indirectly such that they alter the post-translational modification of tubulin. Further investigation into their mechanism of action and evaluation of their anticancer efficacy will help to develop novel regimens that are superior to existingapproaches.

引用

页码：329 / 343

页数：15

共 114 条

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