Lack of carcinogenicity of thiamphenicol in F344 rats

被引：10

作者：

Kitamura, T ^{[1
]}

Ando, J ^{[1
]}

Ishihara, R ^{[1
]}

Takano, S ^{[1
]}

Iijima, T ^{[1
]}

Nishimura, S ^{[1
]}

Yoshida, M ^{[1
]}

Takahashi, M ^{[1
]}

Maekawa, A ^{[1
]}

机构：

[1] Sasaki Inst, Dept Pathol, Chiyoda Ku, Tokyo 101, Japan

来源：

FOOD AND CHEMICAL TOXICOLOGY | 1997年 / 35卷 / 10-11期

关键词：

D O I：

10.1016/S0278-6915(97)00114-2

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The carcinogenicity of thiamphenicol (TAP), an antibiotic drug, was examined in Fischer 344 rats of both sexes. TAP was given ad lib. in drinking water at levels of 0 (control), 125 or 250 ppm to groups of 50 male and 50 female rats for 2 yr. The treatment did not affect mortality and no toxic lesions were specifically induced. Furthermore, the incidence of tumours in the treated groups did not show any significant dose-related increase as compared with the control group. The results thus indicate that TAP is neither toxic nor carcinogenic for any organs or tissues of F344 rats when given continuously at levels of 125 or 250 ppm in drinking water for 2 yr. (C) 1997 Elsevier Science Ltd. All rights reserved.

引用

页码：1075 / 1080

页数：6

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