Galectin-3 in Atrial Fibrillation: Mechanisms and Therapeutic Implications

被引：53
|
作者：
Clementy, Nicolas [1 ]
Piver, Eric [2 ]
Bisson, Arnaud [1 ]
Andre, Clementine [1 ]
Bernard, Anne [1 ]
Pierre, Bertrand [1 ]
Fauchier, Laurent [1 ]
Babuty, Dominique [1 ]
机构：
[1] Francois Rabelais Univ, Trousseau Hosp, Cardiol Dept, F-37000 Tours, France
[2] Francois Rabelais Univ, Trousseau Hosp, Biochem Dept, F-37000 Tours, France
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 04期
关键词：
galectin-3; atrial fibrillation; ablation; LATE GADOLINIUM ENHANCEMENT; SMOOTH MUSCLE ACTIN; CATHETER ABLATION; SERUM GALECTIN-3; HEART-FAILURE; MYOCARDIAL-INFARCTION; CLINICAL-OUTCOMES; FIBROSIS; ASSOCIATION; DIFFERENTIATION;
D O I：
10.3390/ijms19040976
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Maintenance of atrial fibrillation is a complex mechanism, including extensive electrical and structural remodeling of the atria which involves progressive fibrogenesis. Galectin-3 is a biomarker of fibrosis, and, thus, may be involved in atrial remodeling in atrial fibrillation patients. We review the role of galectin-3 in AF mechanisms and its potential therapeutic implications.
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页数：14
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