Role of AMPA and NMDA receptors in the nucleus accumbens shell in turning behaviour of rats: interaction with dopamine receptors

被引:26
作者
Ikeda, H
Akiyama, G
Fujii, Y
Minowa, R
Koshikawa, N
Cools, AR
机构
[1] Nihon Univ, Sch Dent, Dept Pharmacol, Chiyoda Ku, Tokyo 1018310, Japan
[2] Nihon Univ, Sch Dent, Div Oral & Craniomaxillofacial Res, Dent Res Ctr,Chiyoda Ku, Tokyo 1018310, Japan
[3] Sci Univ Tokyo, Fac Pharmaceut Sci, Dept Pharmacol, Shinjuku Ku, Tokyo 1620826, Japan
[4] Univ Nijmegen, Dept Psychoneuropharmacol, NL-6500 HB Nijmegen, Netherlands
基金
澳大利亚研究理事会;
关键词
dopamine receptors; NMDA receptors; AMPA receptors; turning behaviour; the shell of the nucleus accumbens;
D O I
10.1016/S0028-3908(02)00334-9
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The role of AMPA and NMDA receptors in the shell of the nucleus accumbens in turning behaviour of rats was investigated. Unilateral injection of the AMPA receptor agonist, AMPA (0.25, 0.4, 0.5 and 1 mug), into the shell of the nucleus accumbens dose-dependently produced contraversive pivoting, namely tight head-to-tail turning marked by abnormal hindlimb backward stepping, while injection of AMPA (0.5 mug) into the core produced only a marginal effect. This shell-specific AMPA effect was dose-dependently inhibited by the AMPA receptor antagonist, NBQX (1 and 10 ng), which alone did not produce turning behaviour. The AMPA-induced pivoting was also dose-dependently inhibited by the non-competitive NMDA receptor antagonist, MK-801 (0.1 and 0.5 mug). Neither MK-801 (0.1, 0.5 and 5 mug) nor the NMDA receptor agonist, NMDA (0.5 and 1 mug), injected unilaterally into the shell, produced turning behaviour. Unilateral injection of a mixture of dopamine D, (SKF 38393, 5 mug) and D-2 (quinpirole, 10 mug) receptor agonists into the shell has been found to elicit contraversive pivoting. The dopamine D-1/D-2 receptor antagonist, cis-(Z)-flupentixol (1 and 10 mug), injected into the shell, in doses known to block dopamine D-1/D-2 receptor-mediated pivoting, also significantly inhibited AMPA (0.5 mug)-induced pivoting. Moreover, both NBQX (I and 10 ng) and MK-801 (0.1 and 0.5 mug), injected into the shell, significantly inhibited dopamine D-1/D-2 receptor-mediated pivoting. It is therefore concluded that unilateral stimulation of AMPA receptors in the shell of the nucleus accumbens can elicit contraversive pivoting, and that both AMPA and dopamine D-1/D-2 receptors play a critical role in shell-specific pivoting in contrast to NMDA receptors that at best play only a modulatory role. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:81 / 87
页数:7
相关论文
共 37 条
[1]   NBQX INHIBITS AMPA-INDUCED LOCOMOTION AFTER INJECTION INTO THE NUCLEUS-ACCUMBENS [J].
BOLDRY, RC ;
KELLAND, MD ;
ENGBER, TM ;
CHASE, TN .
BRAIN RESEARCH, 1993, 600 (02) :331-334
[2]   THE IMPORTANCE OF DOPAMINERGIC NEUROTRANSMISSION IN THE HYPERMOTILITY RESPONSE PRODUCED BY THE ADMINISTRATION OF N-METHYL-D-ASPARTIC ACID INTO THE NUCLEUS ACCUMBENS [J].
BOLDRY, RC ;
URETSKY, NJ .
NEUROPHARMACOLOGY, 1988, 27 (06) :569-577
[3]   THE ROLE OF ENDOGENOUS DOPAMINE IN THE HYPERMOTILITY RESPONSE TO INTRAACCUMBENS AMPA [J].
BOLDRY, RC ;
WILLINS, DL ;
WALLACE, LJ ;
URETSKY, NJ .
BRAIN RESEARCH, 1991, 559 (01) :100-108
[4]   Dopaminergic agonists administered into the nucleus accumbens: Effects on extracellular glutamate and on locomotor activity [J].
Dalia, A ;
Uretsky, NJ ;
Wallace, LJ .
BRAIN RESEARCH, 1998, 788 (1-2) :111-117
[5]   Locomotor activity induced by the non-competitive N-methyl-D-aspartate antagonist, MK-801:: Role of nucleus accumbens efferent pathways [J].
De Leonibus, E ;
Mele, A ;
Oliverio, A ;
Pert, A .
NEUROSCIENCE, 2001, 104 (01) :105-116
[6]   EFFECTS OF EXCITATORY AMINO-ACIDS ON LOCOMOTOR-ACTIVITY AFTER BILATERAL MICROINJECTION INTO THE RAT NUCLEUS ACCUMBENS - POSSIBLE DEPENDENCE ON DOPAMINERGIC MECHANISMS [J].
DONZANTI, BA ;
URETSKY, NJ .
NEUROPHARMACOLOGY, 1983, 22 (08) :971-&
[7]   ANTAGONISM OF THE HYPERMOTILITY RESPONSE INDUCED BY EXCITATORY AMINO-ACIDS IN THE RAT NUCLEUS ACCUMBENS [J].
DONZANTI, BA ;
URETSKY, NJ .
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1984, 325 (01) :1-7
[8]   STIMULATORY EFFECT OF N-METHYL ASPARTATE ON LOCOMOTOR-ACTIVITY AND TRANSMITTER RELEASE FROM RAT NUCLEUS-ACCUMBENS [J].
HAMILTON, MH ;
DEBELLEROCHE, JS ;
GARDINER, IM ;
HERBERG, LJ .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1986, 25 (05) :943-948
[9]   NMDA RECEPTORS AND INVIVO DOPAMINE RELEASE IN THE NUCLEUS-ACCUMBENS AND NUCLEUS-CAUDATUS [J].
IMPERATO, A ;
SCROCCO, MG ;
BACCHI, S ;
ANGELUCCI, L .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 187 (03) :555-556
[10]   DOPAMINE RELEASE IN THE NUCLEUS-CAUDATUS AND IN THE NUCLEUS-ACCUMBENS IS UNDER GLUTAMATERGIC CONTROL THROUGH NON-NMDA RECEPTORS - A STUDY IN FREELY-MOVING RATS [J].
IMPERATO, A ;
HONORE, T ;
JENSEN, LH .
BRAIN RESEARCH, 1990, 530 (02) :223-228