Generation of free oxygen radicals in the pathogenesis of experimental acute reflux pancreatitis

被引：20

作者：

Shabanov, VV ^{[1
]}

Sarbaeva, NN ^{[1
]}

Milyakova, MN ^{[1
]}

机构：

[1] Samara Mil Med Inst, Dept Surg, Samara, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2002年 / 134卷 / 01期

关键词：

acute pancreatitis; superoxide dismutase; allopurinol; free oxygen radicals;

D O I：

10.1023/A:1020644302486

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In dogs with acute reflux pancreatitis specific activity of superoxide dismutase in the pancreas rapidly increased (over 15 min). Activation of this enzyme by free oxygen radicals was demonstrated in in vitro experiments. Treatment with allopurinol prevented activation of superoxide dismutase. Our results indicate that superoxide ions are generated in the pancreas at the early stage of acute reflux pancreatitis due to activation of xanthine oxidase.

引用

页码：26 / 27

页数：2

共 12 条

[1]

BLOECHLE C, 1998, J NEUROPHYSIOL, V274, pG42

[2] Oxidative stress in distant organs and the effects of allopurinol during experimental acute pancreatitis [J].