Effects of Depressive-Like Behavior of Rats on Brain Glutamate Uptake

被引：37

作者：

Almeida, Roberto Farina ^{[1
]}

Thomazi, Ana Paula ^{[1
]}

Godinho, Graca Fabiana ^{[1
]}

Morales Saute, Jonas Alex ^{[2
]}

Wofchuk, Susana Tchernin ^{[1
]}

Souza, Diogo Onofre ^{[1
]}

Ganzella, Marcelo ^{[1
]}

机构：

[1] Univ Fed Rio Grande do Sul, Dept Bioquim, Inst Ciencias Basicas Saude, BR-90035003 Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande do Sul, Programa Ciencias Med, BR-90035003 Porto Alegre, RS, Brazil

来源：

NEUROCHEMICAL RESEARCH | 2010年 / 35卷 / 08期

关键词：

Stress behavior; Depression; Learned helplessness paradigm; Glutamate uptake; Hippocampus; NMDA RECEPTOR COMPLEX; METHYL-D-ASPARTATE; NATIONAL COMORBIDITY SURVEY; AMINO-ACID TRANSPORTER; STRESSFUL LIFE EVENTS; LEARNED HELPLESSNESS; MAJOR DEPRESSION; PREFRONTAL CORTEX; MOOD DISORDERS; BASAL GANGLIA;

D O I：

10.1007/s11064-010-0169-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Learned helplessness paradigm is a widely accepted animal model of depressive-like behavior based on stress. Glutamatergic system is closely involved with the stress-neurotoxicity in the brain and recently it is pointed to have a relevant role in the pathophysiology of depression disorder. Glutamate uptake is the main mechanism to terminate the glutamatergic physiological activity and to neuroprotection against excitotoxicity. We investigated the profile of glutamate uptake in female rats submitted to the learned helplessness paradigm and to different classes of stress related to the paradigm, in slices of brain cortex, striatum and hippocampus. Glutamate uptake in slices of hippocampus differ between learned helplessness (LH) and non-learned helplessness (NLH) animals immediately persisting up to 21 days after the paradigm. In addition, there were a decrease of glutamate uptake in the three brain structures analyzed at 21 days after the paradigm for LH animals. These results may contribute to better understand the role of the glutamatergic system on the depressive-like behavior.

引用

页码：1164 / 1171

页数：8

共 67 条

[21] Impaired escape performance and enhanced conditioned fear in rats following exposure to an uncontrollable stressor are mediated by glutamate and nitric oxide in the dorsal raphe nucleus [J].