Running exercise protects oligodendrocytes in the medial prefrontal cortex in chronic unpredictable stress rat model

被引:45
|
作者
Luo, Yanmin [1 ,2 ]
Xiao, Qian [1 ,3 ]
Wang, Jin [1 ,4 ]
Jiang, Lin [1 ,4 ]
Hu, Menglan [1 ,4 ]
Jiang, Yanhong [1 ,4 ]
Tang, Jing [1 ,4 ]
Liang, Xin [1 ,4 ]
Qi, Yingqiang [1 ,4 ]
Dou, Xiaoyun [5 ]
Zhang, Yi [1 ,4 ]
Huang, Chunxia [1 ,2 ]
Chen, Linmu [1 ,4 ]
Tang, Yong [1 ,4 ]
机构
[1] Chongqing Med Univ, Lab Stem Cells & Tissue Engn, Chongqing 400016, Peoples R China
[2] Chongqing Med Univ, Dept Physiol, Chongqing 400016, Peoples R China
[3] Chongqing Med Univ, Dept Radioact Med, Chongqing 400016, Peoples R China
[4] Chongqing Med Univ, Dept Histol & Embryol, Chongqing 400016, Peoples R China
[5] Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China
基金
中国国家自然科学基金;
关键词
INCREASES CELL-PROLIFERATION; MAJOR DEPRESSIVE DISORDER; WHITE-MATTER; ANTERIOR CINGULATE; VOLUNTARY EXERCISE; COGNITIVE FUNCTION; PHYSICAL-ACTIVITY; CEREBRAL-CORTEX; MOOD DISORDERS; GLIAL-CELLS;
D O I
10.1038/s41398-019-0662-8
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Previous postmortem and animal studies have shown decreases in the prefrontal cortex (PFC) volume and the number of glial cells in the PFC of depression. Running exercise has been shown to alleviate depressive symptoms. However, the effects of running exercise on the medial prefrontal cortex (mPFC) volume and oligodendrocytes in the mPFC of depressed patients and animals have not been investigated. To address these issues, adult male rats were subjected to chronic unpredictable stress (CUS) for 5 weeks, followed by treadmill running for 6 weeks. Then, the mPFC volume and the mPFC oligodendrocytes were investigated using stereology, immunohistochemistry, immunofluorescence and western blotting. Using a CUS paradigm that allowed for the analysis of anhedonia, we found that running exercise alleviated the deficits in sucrose preference, as well as the decrease in the mPFC volume. Meanwhile, we found that running exercise significantly increased the number of CNPase(+) oligodendrocytes and Olig(2+) oligodendrocytes, reduced the ratio between Olig(2+)/NG(2+) oligodendrocytes and Olig(2+) oligodendrocytes and increased myelin basic protein (MBP), CNPase and Olig2 protein expression in the mPFC of the CUS rat model. However, running exercise did not change NG(2+) oligodendrocyte number in the mPFC in these rats. These results indicated that running exercise promoted the differentiation of oligodendrocytes and myelin-forming ability in the mPFC in the context of depression. These findings suggest that the beneficial effects of running exercise on mPFC volume and oligodendrocytes in mPFC might be an important structural basis for the antidepressant effects of running exercise.
引用
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页数:11
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