Membrane rafting: From apical sorting to phase segregation

被引:65
作者
Coskun, Unal [1 ]
Simons, Kai [1 ]
机构
[1] Max Planck Inst Mol Cell Biol & Genet, Dresden, Germany
关键词
Lipid rafts; Membrane heterogeneity; Resting state; Phase separation; Apical transport; GPI-ANCHORED PROTEINS; TRANS-GOLGI-NETWORK; INFLUENZA-VIRUS HEMAGGLUTININ; CHOLESTEROL-BINDING PROTEIN; LIQUID-ORDERED DOMAINS; GROWTH-FACTOR RECEPTOR; SEMLIKI-FOREST-VIRUS; PLASMA-MEMBRANE; LIPID RAFTS; CELL-SURFACE;
D O I
10.1016/j.febslet.2009.12.043
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In this review we describe the history of the development of the raft concept for membrane sub-compartmentalization. From its early beginnings as a mechanism for apical sorting in epithelial cells the concept has evolved to a general principle for membrane organisation. After a shaky start with crude methodology based on detergent extraction the field has become increasingly sophisticated, employing a host of different methods that support the existence of dynamic raft domains in membranes. These are composed of fluctuating nanoscale assemblies of sphingolipid, cholesterol and proteins that can be stabilized to coalesce, forming platforms that function in membrane signalling and trafficking. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
引用
收藏
页码:1685 / 1693
页数:9
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