Calcium dynamics in gonadotropin-releasing hormone neurons

被引：28

作者：

Jasoni, Christine L. ^{[1
]}

Romano, Nicola ^{[1
]}

Constantin, Stephanie ^{[1
]}

Lee, Kiho ^{[1
]}

Herbison, Allan E. ^{[1
]}

机构：

[1] Univ Otago, Ctr Neuroendocrinol, Dept Physiol, Dunedin 9054, New Zealand

来源：

FRONTIERS IN NEUROENDOCRINOLOGY | 2010年 / 31卷 / 03期

关键词：

GnRH; LHRH; Calcium; GABA; Glutamate; Electrophysiology; Monkey; Mouse; GT1; Embryo; EMBRYONIC OLFACTORY PLACODE; RAT SUPRAOPTIC NUCLEUS; GAMMA-AMINOBUTYRIC-ACID; PRIMARY-CELL CULTURE; SMOOTH-MUSCLE-CELLS; GNRH NEURONS; INTRACELLULAR CA2+; GENE-EXPRESSION; LHRH NEURONS; AFTERHYPERPOLARIZATION CURRENTS;

D O I：

10.1016/j.yfrne.2010.05.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The gonadotropin-releasing hormone (GnRH) neurons represent the key output cells of the neuronal network controlling fertility. Intracellular calcium ion concentration ([Ca2+](i)) is likely to be a key signaling tool used by GnRH neurons to regulate and co-ordinate multiple cell processes. This review examines the dynamics and control of [Ca2+](i) in GT1 cells, embryonic GnRH neurons in the nasal placode culture, and adult GnRH neurons in the acute brain slice preparation. GnRH neurons at all stages of development display spontaneous [Ca2+](i) transients driven, primarily, by their burst firing. However, the intracellular mechanisms generating [Ca2+](i) transients, and the control of [Ca2+](i) by neurotransmitters, varies markedly across the different developmental stages. The functional roles of [Ca2+](i) transients are beginning to be unraveled with one key action being that of regulating the dynamics of GnRH neuron burst firing. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：259 / 269

页数：11

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