Renal markers cystatin C and neutrophil gelatinase-associated lipocalin (NGAL) in postmortem samples

被引：0
作者：
Keltanen, Terhi [1 ]
Walta, Anna-Mari [1 ]
Salonen, Satu [1 ]
Sajantila, Antti [1 ]
Lindroos, Katarina [1 ]
机构：
[1] Univ Helsinki, Dept Forens Med, POB 40, FIN-00014 Helsinki, Finland
来源：
FORENSIC SCIENCE MEDICINE AND PATHOLOGY | 2016年 / 12卷 / 02期
关键词：
Postmortem; NGAL; Creatinine; Cystatin C; ACUTE KIDNEY INJURY; URIC-ACID LEVELS; UREA NITROGEN; CREATININE; BIOMARKERS; SERUM;
D O I：
10.1007/s12024-016-9760-6
中图分类号：
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号：
0301 ; 10 ;
摘要：
Renal markers may provide valuable information for cause of death (CoD) investigation when assessing the influence of impaired kidney function. A commonly used marker, creatinine (Cr), increases due to kidney injury and is known to be reasonably stable in postmortem (PM) samples. More sensitive markers are needed, as the increase of serum Cr level only occurs after relatively severe renal damage. We evaluated two markers, cystatin C and neutrophil gelatinase-associated lipocalin (NGAL), in addition to Cr. To the best of our knowledge this was the first study to investigate cystatin C and NGAL in a postmortem (PM) context. Cr, cystatin C, and NGAL were measured from PM blood in 39 autopsy cases. NGAL was also measured from urine in 16 cases. Cystatin C and NGAL were analyzed using ELISA, Cr measurements were performed with Jaffe method. Correlations of these markers were evaluated. Both, blood cystatin C and NGAL, levels showed significant correlation with Cr (p = 0.05 and p = 0.01, respectively). Cystatin C and NGAL in blood are promising markers for further studies with PM samples.
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收藏
页码：189 / 192
页数：4
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