Acute myeloid leukemia associated with t(10;17)(p13-15;q12-21) and phagocyte activity by leukemic blasts: a clinical study and review of the literature

Translocation (10;17)(p13-15;q12-21) in acute leukemia is rarely reported in the literature. Here, we present both a novel t(10;17) case study and a review of relevant literature on t(10;17) in acute leukemia (10 cases). In summary, we came to the following preliminary conclusions: t(10; I 7) is associated with poorly differentiated acute leukemia subtype [90%; eight cases of acute myeloid leukemia (AML MO, M1) and one case of acute undifferentiated leukemia], phagocytic activity by blasts occurs (30%), and the survival time was short in three of the seven t( I 0;1 7) cases for whom follow-up data were available (median, 8 months). More clinical studies concerning the prognosis, treatment response, and survival of patients with t(10;17) are necessary. (C) 2010 Elsevier Inc. All rights reserved.