Leukocytes navigate by compass:: roles of PI3Kγ and its lipid products

被引：244

作者：

Rickert, P

Weiner, OD

Wang, F

Bourne, HR

Servant, G

机构：

[1] Univ Calif San Francisco, Dept Mol & Cellular Pharmacol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA

来源：

TRENDS IN CELL BIOLOGY | 2000年 / 10卷 / 11期

关键词：

D O I：

10.1016/S0962-8924(00)01841-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Morphologic polarity is necessary for the motility of mammalian cells. In leukocytes responding to a chemoattractant, this Polarity is regulated by activities of small Rho guanosine triphosphatases (Rho GTPases) and the phosphoinositide 3-kinases (PI3Ks). Moreover, in neutrophils, lipid products of PI3Ks appear to regulate activation of Rho GTPases, are required fur cell motility and accumulate asymmetrically to the plasma membrame at the leading edge of polarized cells. By spatially regulating Rho GTPases and organizing the leading edge of the cell, PI3Ks and their lipid products could play pivotal roles not only in establishing leukocyte polarity but also as compass molecules that tell the cell where to crawl.

引用

收藏

页码：466 / 473

页数：8

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