Synthesis of hollow nanocages MOF-5 as drug delivery vehicle to solve the load-bearing problem of insoluble antitumor drug oleanolic acid (OA)

被引：53

作者：

Zhang, Lei ^{[1
]}

Chen, Yan ^{[2
]}

Shi, Rui ^{[1
]}

Rang, Tingguo ^{[1
]}

Pang, Guangsheng ^{[2
]}

Wang, Boran ^{[2
]}

Zhao, Yue ^{[2
]}

Zeng, Xu ^{[2
]}

Zou, Changxin ^{[1
]}

Wu, Peng ^{[1
]}

Li, Jiayang ^{[1
]}

机构：

[1] Liaoning Univ Tradit Chinese Med, Dalian 116600, Peoples R China

[2] Jilin Univ, Coll Chem, State Key Lab Inorgan Synth & Preparat Chem, Changchun 130012, Jilin, Peoples R China

来源：

INORGANIC CHEMISTRY COMMUNICATIONS | 2018年 / 96卷

关键词：

Metal-organic framework; Oleanolic acid; Drug delivery; Antitumor; METAL-ORGANIC FRAMEWORKS; CONTROLLED-RELEASE; ZN-2(BDC)(2)(DABCO); LIPOSOMES; HYBRID;

D O I：

10.1016/j.inoche.2018.07.029

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Oleanolic acid is an antitumor traditional Chinese medicine component whose oral efficacy and clinical applications are limited because of its strong hydrophobicity. Recently, the use of metal-organic frameworks (MOFs) as drug carriers has attracted considerable research attention. In this study, the hollow structure of MOF-5 was synthesized. Its drug loading and drug release capacity were studied. The human ovarian cancer SK-OV-3 cell line was selected to study the drug loading system, cytotoxicity, and cellular uptake. We concluded that a hollow MOF with an excellent morphology was successfully fabricated in the experiment; it increased the drug loading capacity, achieved a more ideal sustained-release effect, improved the treatment efficiency of the hydrophobic Chinese medicine component, and provided a relatively efficient drug loading material.

引用

页码：20 / 23

页数：4

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