Decrease of ventral tegmental area dopamine neuronal activity in nicotine withdrawal rats

被引：24

作者：

Liu, ZH ^{[1
]}

Jin, WQ ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Mat Med, Dept Pharmacol, Shanghai 201203, Peoples R China

来源：

NEUROREPORT | 2004年 / 15卷 / 09期

关键词：

dopamine; electrophysiology; nicotine; ventral tegmental area; withdrawal;

D O I：

10.1097/01.wnr.0000126218.25235.b6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study was designed to examine the ventral tegmental area (VTA) dopamine neuronal activity in nicotine withdrawal rats by means of in vivo single-unit extracellular recordings. Animals were treated with nicotine base (6 mg/kg/day, s.c) four times daily for 12 days. One day after the last nicotine administration, the firing rates of the VTA dopamine neurons were found to be significantly decreased. Following 2, 3, 5 and 10 days of nicotine withdrawal, however, the firing rates returned to the control levels. The number of spontaneously active dopamine cells was not altered at any time points. The results indicate that the VTA dopamine neuronal activity is reduced during the first day of nicotine withdrawal.

引用

收藏

页码：1479 / 1481

页数：3

相关论文

共 21 条

[1] THE EFFECTS OF ACUTE AND REPEATED NICOTINE TREATMENT ON NUCLEUS-ACCUMBENS DOPAMINE AND LOCOMOTOR-ACTIVITY [J].

BENWELL, MEM ;

BALFOUR, DJK .

BRITISH JOURNAL OF PHARMACOLOGY, 1992, 105 (04) :849-856

[2] Dissociation of physical abstinence signs from changes in extracellular dopamine in the nucleus accumbens and in the prefrontal cortex of nicotine dependent rats [J].

Carboni, E ;

Bortone, L ;

Giua, C ;

Di Chiara, G .

DRUG AND ALCOHOL DEPENDENCE, 2000, 58 (1-2) :93-102

[3] Mesolimbic dopaminergic decline after cannabinoid withdrawal [J].

Diana, M ;

Melis, M ;

Muntoni, AL ;

Gessa, GL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (17) :10269-10273

[4] PROFOUND DECREMENT OF MESOLIMBIC DOPAMINERGIC NEURONAL-ACTIVITY DURING ETHANOL WITHDRAWAL SYNDROME IN RATS - ELECTROPHYSIOLOGICAL AND BIOCHEMICAL-EVIDENCE [J].

DIANA, M ;

PISTIS, M ;

CARBONI, S ;

GESSA, GL ;

ROSSETTI, ZL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (17) :7966-7969

[5]

DIANA M, 1995, J PHARMACOL EXP THER, V272, P781

[6] Dramatic decreases in brain reward function during nicotine withdrawal [J].

Epping-Jordan, MP ;

Watkins, SS ;

Koob, GF ;

Markou, A .

NATURE, 1998, 393 (6680) :76-79

[7] Excitatory and inhibitory responses of dopamine neurons in the ventral tegmental area to nicotine [J].

Erhardt, S ;

Schwieler, L ;

Engberg, L .

SYNAPSE, 2002, 43 (04) :227-237

[8] Nicotine modifies the activity of ventral tegmental area dopaminergic neurons and hippocampal GABAergic neurons [J].

Fisher, JL ;

Pidoplichko, VI ;

Dani, JA .

JOURNAL OF PHYSIOLOGY-PARIS, 1998, 92 (3-4) :209-213

[9] Effects of nicotine withdrawal on central dopaminergic systems [J].

Fung, YK ;

Schmid, MJ ;

Anderson, TM ;

Lau, YS .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1996, 53 (03) :635-640

[10] INTRACELLULAR AND EXTRACELLULAR ELECTROPHYSIOLOGY OF NIGRAL DOPAMINERGIC-NEURONS .1. IDENTIFICATION AND CHARACTERIZATION [J].

GRACE, AA ;

BUNNEY, BS .

NEUROSCIENCE, 1983, 10 (02) :301-&