Studies on acyl pyrrolidine inhibitors of HCV RNA-dependent RNA polymerase to identify a molecule with replicon antiviral activity

被引：40

作者：

Burton, George

Ku, Thomas W.

Carr, Thomas J.

Kiesow, Terry

Sarisky, Robert T.

Lin-Goerke, Juill

Hofmann, Glenn A.

Slater, Martin J.

Haigh, David

Dhanak, Dashyant

Johnson, Victor K.

Parry, Nigel R.

Thommes, Pia

机构：

[1] GlaxoSmithKline, Collegeville, PA 19426 USA

[2] GlaxoSmithKline, Stevenage SG1 2NY, Herts, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 07期

关键词：

hepatitis C virus; RNA-dependent RNA polymerase; HCVNS5B; N-acyl pyrrolidines; HCV replicon; SAR;

D O I：

10.1016/j.bmcl.2007.01.034

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The SAR development is described for a series of N-acyl pyrrolidine inhibitors of the Hepatitis C virus RNA-dependent RNA polymerase, NS5B, from tractable Delta 21 enzyme inhibitors to an example with antiviral activity in a cellular assay (HCV replicon). (c) 2007 Elsevier Ltd. All rights reserved.

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页码：1930 / 1933

页数：4

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