Reactions of salicylaldehydes with alkyl cyanoacetates on the surface of solid catalysts:: syntheses of 4H-chromene derivatives

被引：167

作者：

Yu, NF ^{[1
]}

Aramini, JM ^{[1
]}

Germann, MW ^{[1
]}

Huang, ZW ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Jefferson Med Coll, Kimmel Canc Ctr, Philadelphia, PA 19107 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 36期

关键词：

4H-chromene; cyclization; Bcl-2; protein; apoptosis; anti-cancer agents;

D O I：

10.1016/S0040-4039(00)01195-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Substituted 4H-chromene derivatives are a new class of compounds that bind Bcl-2 protein and induce apoptosis in tumor cells. Here we report an efficient synthetic method for the preparation of these compounds from salicylaldehyde derivatives and alkyl cyanoacetates under solid-phase catalysis. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：6993 / 6996

页数：4

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