Association Study of Serotonin 3 Receptor Subunit Gene Variants in Antipsychotic-Induced Weight Gain

被引：3
作者：
Zai, Clement C. [1 ,2 ,3 ]
Tiwari, Arun K. [1 ,2 ]
Chowdhury, Nabilah I. [1 ]
Brandl, Eva J. [1 ,2 ,4 ]
Shaikh, Sajid A. [1 ]
Freeman, Natalie [1 ]
Lieberman, Jeffrey A. [5 ,6 ]
Meltzer, Herbert Y. [7 ]
Kennedy, James L. [1 ,2 ]
Mueller, Daniel J. [1 ,2 ]
机构：
[1] Univ Toronto, Neurogenet Sect, Campbell Family Mental Hlth Res Inst, Ctr Addict & Mental Hlth, Toronto, ON, Canada
[2] Univ Toronto, Dept Psychiat, Toronto, ON, Canada
[3] Univ Toronto, Lab Med & Pathobiol, Toronto, ON, Canada
[4] Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Berlin, Germany
[5] Columbia Univ, New York State Psychiat Inst, Coll Phys & Surg,New York Presbyterian Hosp, Dept Psychiat,Lieber Ctr Schizophrenia Res, New York, NY USA
[6] Columbia Univ, Med Ctr, New York, NY USA
[7] Northwestern Univ, Dept Psychiat & Beh Sci, Feinberg Sch Med, Chicago, IL 60611 USA
来源：
NEUROPSYCHOBIOLOGY | 2016年 / 74卷 / 03期
基金：
美国国家卫生研究院; 加拿大健康研究院;
关键词：
Serotonin 3A and 3B receptor genes (HTR3A; HTR3B); Schizophrenia; Antipsychotic-induced weight gain; Pharmacogenetics; 5-HT3; ANTAGONIST; SCHIZOPHRENIA; CLOZAPINE; COMMON; PHARMACOGENETICS; ONDANSETRON; HOMEOSTASIS;
D O I：
10.1159/000457903
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Background: Schizophrenia (SCZ) is a chronic severe neuropsychiatric disorder, where pharmacological treatment has been hindered by adverse effects, including antipsychotic-induced weight gain (AIWG) and related complications. Genetic studies have been exploring the appetite regulation and energy homeostasis pathways in AIWG with some promising leads. The serotonin system has been shown to participate in these pathways. Methods: In the current study, we examined single nucleotide polymorphisms across the serotonin receptor genes HTR3A and HTR3B. Prospective weight change was assessed for a total of 149 SCZ patients of European ancestry. Results: We did not find the tested HTR3A or HTR3B gene markers to be associated with AIWG in our sample. Conclusion: Our preliminary findings suggest that these receptors may not play a major role in predicting AIWG. (C) 2017 S. Karger AG, Basel
引用
收藏
页码：169 / 175
页数：7
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