Soluble ST2 Testing: A Promising Biomarker in the Management of Heart Failure

被引：92

作者：

Villacorta, Humberto ^{[1
]}

Maisel, Alan S. ^{[2
]}

机构：

[1] Univ Fed Fluminense, Posgrad Ciencias Cardiovasc, BR-24033900 Niteroi, RJ, Brazil

[2] Univ Calif San Diego, Div Cardiovasc Med, San Diego, CA 92103 USA

来源：

ARQUIVOS BRASILEIROS DE CARDIOLOGIA | 2016年 / 106卷 / 02期

关键词：

Heart Failure / therapy; Biomarkers; Pharmacological; Receptors; Interleukin; Prognosis; FAMILY-MEMBER ST2; CARDIAC STRUCTURE; MORTALITY; RECEPTOR; ASSOCIATION; THERAPY; DEATH; PREDICTION; PROGNOSIS; PROTEIN;

D O I：

10.5935/abc.20150151

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

ST2 is a member of the interleukin-1 receptor family biomarker and circulating soluble ST2 concentrations are believed to reflect cardiovascular stress and fibrosis. Recent studies have demonstrated soluble ST2 to be a strong predictor of cardiovascular outcomes in both chronic and acute heart failure. It is a new biomarker that meets all required criteria for a useful biomarker. Of note, it adds information to natriuretic peptides (NPs) and some studies have shown it is even superior in terms of risk stratification. Since the introduction of NPs, this has been the most promising biomarker in the field of heart failure and might be particularly useful as therapy guide.

引用

页码：145 / 152

页数：8

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