Asymmetric hydrogenation of enol phosphinates by iridium catalysts having N,P ligands

被引：71
|
作者：
Cheruku, Pradeep [1 ]
Gohil, Suresh [1 ]
Andersson, Pher G. [1 ]
机构：
[1] Dept Biochem & Organ Chem, SE-75123 Uppsala, Sweden
来源：
ORGANIC LETTERS | 2007年 / 9卷 / 09期
关键词：
D O I：
10.1021/ol070325l
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Enol phosphinates, which are structural analogues of enol acetates, have for the first time been employed as substrates for Ir-catalyzed asymmetric hydrogenation. A number of enol phosphinates have been synthesized and reduced successfully with up to and above 99% ee.
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收藏
页码：1659 / 1661
页数：3
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