Unusual ent-atisane type diterpenoids with 2-oxopropyl skeleton from the roots of Euphorbia ebracteolata and their antiviral activity against human rhinovirus 3 and enterovirus 71

被引：20

作者：

Wang, Bo ^{[1
]}

Wei, Yunlong ^{[1
]}

Zhao, Xinyu ^{[1
]}

Tian, Xiangge ^{[1
]}

Ning, Jing ^{[1
]}

Zhang, Baojing ^{[1
]}

Deng, Sa ^{[1
]}

Li, Dawei ^{[2
]}

Ma, Xiaochi ^{[1
]}

Wang, Chao ^{[1
]}

机构：

[1] Dalian Med Univ, Natl & Local Joint Engn Res Ctr Drug Dev Neurodeg, Coll Med Lab, Coll Pharm,Acad Integrat Med, Dalian 116044, Peoples R China

[2] Dalian Med Univ, Affiliated Hosp 1, 222 Zhongshan Rd, Dalian 116011, Peoples R China

来源：

BIOORGANIC CHEMISTRY | 2018年 / 81卷

基金：

中国国家自然科学基金;

关键词：

Euphorbia ebracteolata; Diterpenoids; Atisane; HRV3; EV71; HAYATA; DERIVATIVES; GLYCOSIDES;

D O I：

10.1016/j.bioorg.2018.08.029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two novel ent-atisane type diterpenoids possessing the extra unusal 2-oxopropyl moiety (1 and 2) and four known analogues have been isolated from the roots of Euphorbia ebracteolata. The structures and absolute configurations of these compounds were determined by extensive spectroscopic data analysis, including 2D NMR, single-crystal X-ray crystallography, C-13 NMR calculation, and electronic circular dichroism spectra calculation. Compounds 1 and 2 are the first examples of natural products with ent-atisane type diterpenoids possessing 2-oxopropyl skeleton. Compounds 2, 3, 5, and 6 show antiviral activities against human rhinovirus 3, with IC50 values of 25.27-90.35 mu M. Compounds 5 and 6 showed moderate antiviral activities against EV71 at a concentration of 100 mu M.

引用

页码：234 / 240

页数：7

共 29 条

[1]

[Anonymous], [No title captured]

[2] ENTEROVIRUS-71 ISOLATED FROM CASES OF EPIDEMIC POLIOMYELITIS-LIKE DISEASE IN BULGARIA [J].