Sphingolipid metabolites in neural signalling and function

被引：112

作者：

Colombaioni, L

Garcia-Gil, M

机构：

[1] Univ Pisa, Dept Physiol & Biochem, I-56127 Pisa, Italy

[2] CNR, Inst Neurosci, I-56100 Pisa, Italy

来源：

BRAIN RESEARCH REVIEWS | 2004年 / 46卷 / 03期

关键词：

sphingolipid metabolites; neural signalling; apoptosis;

D O I：

10.1016/j.brainresrev.2004.07.014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Sphingolipid metabolites, such as ceramide, sphingosine, sphingosine-1-phosphate (S1P) and complex sphingolipids (gangliosides), are recognized as molecules capable of regulating a variety of cellular processes. The role of sphingolipid metabolites has been studied mainly in non-neuronal tissues. These studies have underscored their importance as signals transducers, involved in control of proliferation, survival, differentiation and apoptosis. In this review, we will focus on studies performed over the last years in the nervous system, discussing the recent developments and the current perspectives in sphingolipid metabolism and functions. (C) 2004 Elsevier B.V. All rights reserved.

引用

收藏

页码：328 / 355

页数：28

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