A Role for Notch Signalling in Breast Cancer and Endocrine Resistancesssss

被引：48
作者：
Acar, Ahmet [1 ]
Simoes, Bruno M. [2 ]
Clarke, Robert B. [2 ,3 ]
Brennan, Keith [1 ]
机构：
[1] Univ Manchester, Fac Life Sci, Oxford Rd, Manchester M13 9PT, Lancs, England
[2] Univ Manchester, Inst Canc Sci, Breast Biol Grp, Wilmslow Rd, Manchester M20 4BX, Lancs, England
[3] Univ Manchester, Inst Canc Sci, Breast Canc Now Res Unit, Wilmslow Rd, Manchester M20 4BX, Lancs, England
来源：
STEM CELLS INTERNATIONAL | 2016年 / 2016卷
关键词：
ESTROGEN-RECEPTOR; STEM-CELLS; TUMOR ANGIOGENESIS; DOMAIN MUTATIONS; ACTIVATION; EXPRESSION; GENE; MODULATION; TAMOXIFEN; THERAPY;
D O I：
10.1155/2016/2498764
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Over the past decade, there has been growing interest in the Notch signalling pathway within the breast cancer field. This interest stemmed initially from the observation that Notch signalling is aberrantly activated in breast cancer and its effects on various cellular processes including proliferation, apoptosis, and cancer stem cell activity. However more recently, elevated Notch signalling has been correlated with therapy resistance in oestrogen receptor-positive breast cancer. As a result, inhibiting Notch signalling with therapeutic agents is being explored as a promising treatment option for breast cancer patients.
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页数：6
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