Evolution of the CD8 T-cell repertoire during infections

被引：30

作者：

Lin, MY

Selin, LK

Welsh, RM

机构：

[1] Univ Massachusetts, Sch Med, Dept Pathol, Worcester, MA 01655 USA

[2] Univ Massachusetts, Sch Med, Program Immunol & Virol, Worcester, MA 01655 USA

来源：

MICROBES AND INFECTION | 2000年 / 2卷 / 09期

关键词：

evolution; CD8 T cell; virus; LCMV; EBV; Listeria;

D O I：

10.1016/S1286-4579(00)01257-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD8 T cells exist in a dynamic network whose repertoire remains static in the absence of infection but changes in the presence of foreign antigens. Individuals each have unique T-cell repertoires that continually evolve in the presence of antigen and of cross-reactive heterologous antigens, and homeostatic forces drive deletions in T-cell memory pools to accommodate the entry of new memory cells into a finite immune system. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

引用

页码：1025 / 1039

页数：15

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