Effects of Different Loading Patterns on the Trabecular Bone Morphology of the Proximal Femur Using Adaptive Bone Remodeling

被引:13
作者
Banijamali, S. Mohammad Ali [1 ]
Oftadeh, Ramin [1 ,2 ]
Nazarian, Ara [2 ]
Goebel, Ruben [3 ]
Vaziri, Ashkan [1 ]
Nayeb-Hashemi, Hamid [4 ]
机构
[1] Northeastern Univ, Dept Mech & Ind Engn, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Ctr Adv Orthopaed Studies,Dept Orthopaed Surg, Boston, MA 02215 USA
[3] Qatar Univ, Sport Sci Program, Doha 2713, Qatar
[4] Northeastern Univ, Dept Mech & Ind Engn, Snell Engn Ctr 334, Boston, MA 02115 USA
来源
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME | 2015年 / 137卷 / 01期
基金
新加坡国家研究基金会;
关键词
human femur; finite element analysis; trabecular bone; rod; plate; walking; stair climbing; stumbling without falling; FEMORAL FRACTURE LOAD; FINITE-ELEMENT MODEL; CANCELLOUS BONE; HIP-JOINT; ELASTIC PROPERTIES; TISSUE MODULUS; SIMULATION; STIFFNESS; STRENGTH; BEHAVIOR;
D O I
10.1115/1.4029059
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
In this study, the changes in the bone density of human femur model as a result of different loadings were investigated. The model initially consisted of a solid shell representing cortical bone encompassing a cubical network of interconnected rods representing trabecular bone. A computationally efficient program was developed that iteratively changed the structure of trabecular bone by keeping the local stress in the structure within a defined stress range. The stress was controlled by either enhancing existing beam elements or removing beams from the initial trabecular frame structure. Analyses were performed for two cases of homogenous isotropic and transversely isotropic beams. Trabecular bone structure was obtained for three load cases: walking, stair climbing and stumbling without falling. The results indicate that trabecular bone tissue material properties do not have a significant effect on the converged structure of trabecular bone. In addition, as the magnitude of the loads increase, the internal structure becomes denser in critical zones. Loading associated with the stumbling results in the highest density; whereas walking, considered as a routine daily activity, results in the least internal density in different regions. Furthermore, bone volume fraction at the critical regions of the converged structure is in good agreement with previously measured data obtained from combinations of dual X-ray absorptiometry (DXA) and computed tomography (CT). The results indicate that the converged bone architecture consisting of rods and plates are consistent with the natural bone morphology of the femur. The proposed model shows a promising means to understand the effects of different individual loading patterns on the bone density.
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页数:8
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