Trifluoromethylation of various aromatic compounds by CF3I in the presence of Fe(II) compound, H2O2 and dimethylsulfoxide

被引：192

作者：

Kino, Tatsuhito ^{[1
,2
]}

Nagase, Yu ^{[2
]}

Ohtsuka, Yuhki ^{[1
]}

Yamamoto, Kyoko ^{[1
]}

Uraguchi, Daisuke ^{[1
]}

Tokuhisa, Kenji ^{[3
]}

Yamakawa, Tetsu ^{[1
]}

机构：

[1] Sagami Chem Res Ctr, Kanagawa 2521193, Japan

[2] Tokai Univ, Fac Engn, Dept Appl Chem, Hiratsuka, Kanagawa 2591292, Japan

[3] Tosoh F Tech Inc, Yamaguchi 7460006, Japan

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2010年 / 131卷 / 01期

关键词：

Trifluoromethylation; Trifluoromethyl iodide; Trifluoromethyl radical; PHOTOCHEMICAL TRIFLUOROMETHYLATION; RADICAL TRIFLUOROMETHYLATION; SULFUR-DIOXIDE; XENON DIFLUORIDE; TITANIUM ATE; PERFLUOROALKYLATION; TRIFLUOROIODOMETHANE; SUBSTITUTION; CHEMISTRY; TRIFLUOROMETHANESULFINATE;

D O I：

10.1016/j.jfluchem.2009.09.007

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Trifluoromethylation of aromatic and hetero-aromatic compounds by CF3I in the presence of Fe(II) compound, H2O2 and dimethylsulfoxide was investigated. Various trifluoromethylated benzene derivatives, six-membered nitrogen-containing aromatic compounds and five-membered hetero-aromatic compounds were obtained under mild conditions. General orientation of electrophilic substitution of aromatic compounds was observed similarly as reported in other radical trifluoromethylation previously. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：98 / 105

页数：8

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