Ovarian Clear Cell Carcinoma: From Morphology to Molecular Biology

被引：5

作者：

Improta, Giuseppina ^{[1
]}

Pettinato, Angela ^{[2
]}

Hogdall, Estrid ^{[6
]}

Santeusanio, Giuseppe ^{[3
]}

Vatrano, Simona ^{[5
]}

Fraggetta, Filippo ^{[2
]}

Zannoni, Gian Franco ^{[4
]}

机构：

[1] IRCCS CROB, Lab Clin Res & Adv Diagnost, Rionero In Vulture, PZ, Italy

[2] Cannizzaro Hosp, Pathol Unit, Catania, Italy

[3] Tor Vergata Univ, Diagnost Surg Pathol Unit, Rome, Italy

[4] Univ Cattolica Sacro Cuore, Dept Pathol, Rome, Italy

[5] Univ Turin San Luigi Hosp, Dept Oncol, Turin, Italy

[6] Univ Copenhagen, Herlev & Gentofte Hosp, Dept Pathol, Copenhagen, Denmark

来源：

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY | 2019年 / 27卷 / 09期

关键词：

ovarian clear cell carcinoma; ovary; morphology; genetic profile; MICROSATELLITE INSTABILITY; PROTEIN EXPRESSION; PROGNOSTIC-FACTORS; CANCER; ENDOMETRIOSIS; TUMORS; PATHOGENESIS; PIK3CA; ADENOCARCINOMA; SURVIVAL;

D O I：

10.1097/PAI.0000000000000662

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Ovarian clear cell carcinoma (oCCC) is a distinctive subtype of ovarian carcinoma, with peculiar genetic and environmental risk factors, precursor lesions, molecular events during oncogenesis, patterns of spread, and response to treatment. Because of low response to chemotherapy and poor prognosis in advanced stages, there is growing interest in investigating the molecular pathways involved in oCCC development, in order to individualize novel/molecular targeted therapies. Until now, the main molecular genetic changes associated with oCCC remain to be identified, and, although several molecular changes have been reported in clear cell tumors, most studies have analyzed a limited number of cases; therefore, the true prevalence of those changes is not known. The present review will present the clinicopathologic features of oCCC, from morphology to molecular biology, discussing the diagnostic and treatment challenges of this intriguing ovarian carcinoma.

引用

页码：631 / 636

页数：6

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