Pegfilgrastim in Children With Severe Congenital Neutropenia

被引：10
|
作者：
Fioredda, Francesca [1 ]
Calvillo, Michaela
Lanciotti, Marina
Lanza, Tiziana
Giunti, Laura [2 ]
Castagnola, Elio [3 ]
Lorenzi, Ines [4 ]
Tonelli, Rossella [5 ]
Ghezzi, Piero [5 ]
Dufour, Carlo
机构：
[1] Giannina Gaslini Childrens Hosp, Dept Pediat Hematol Oncol & Bone Marrow Transplan, Haematol Unit, I-16147 Genoa, Italy
[2] Meyer Hosp, Dept Pediat, Med Genet Unit, Florence, Italy
[3] Giannina Gaslini Childrens Hosp, Infect Dis Unit, I-16147 Genoa, Italy
[4] Giannina Gaslini Childrens Hosp, Dept Pharm, I-16147 Genoa, Italy
[5] Mario Negri Inst Pharmacol Res, Lab Neuroimmunol, Milan, Italy
来源：
PEDIATRIC BLOOD & CANCER | 2010年 / 54卷 / 03期
关键词：
filgrastim; pegfilgrastim; r-Hu-granulocyte-stimulating factor; severe congenital neutropenia; G-CSF; FILGRASTIM;
D O I：
10.1002/pbc.22350
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Two pediatric patients affected by severe congenital neutropenia (SCN) were treated with 100 mcg/L/dose every 9-12 clays within a Pilot Study (Observatory of the Italian Ministry of Health, Eudract Code 2005-003096-20) on the use of pegfilgrastim in patients with chronic neutropenia. Both children increased their absolute neutrophil Count, reduced their infectious load, and improved their quality of life. Serum concentrations of G-CSF observed in pegfilgrastim mirrored those seen in filgrastim. These data Suggest that pegfilgrastim may be beneficial in SCN patients with an exposure of hematopoietic cells to G-CSF similar to that on filgrastim. Pediatr Blood Cancer 2010;54:465-467. (C) 2009 Wiley-Liss, Inc.
引用
收藏
页码：465 / 467
页数：3
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