In Vivo Pilot Study Regarding the Effects of Amoxicillin on Blood Glucose Levels, Body Weight and Water Intake

被引：0

作者：

Mihalas, Eugenic ^{[1
]}

Balan, Adriana ^{[1
]}

Petcu , Ana ^{[1
]}

Gavrila, Laura ^{[1
]}

Savin, Carmen ^{[1
]}

机构：

[1] Grigore T Popa Univ Med & Pharm, Fac Dent Med, 16 Univ St, Iasi 700115, Romania

来源：

REVISTA DE CHIMIE | 2018年 / 69卷 / 05期

关键词：

mice; amoxicillin; clavulanic acid; blood glucose; water intake; body weight; MICE; CELLS;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Amoxicillin it is the most commonly prescribed antibiotic agent and the first intention in the short-term treatment of infections in children. The aim of this study was to assess the effects of amoxicillin/clavulanic add (AMC) chronic administration on the laboratory mice's body weight (BW), water intake and values of non-fasting blood glucose levels (n-FBG). Thus, twenty-eight C57BL/6 male mice, of similar age, randomly divided into a control and 3 treatment groups (n = 7) received subcutaneous injection, once per day, for 60 days. During the experiment the n-FBG, daily water intake, and BW changes were recorded every 10 days. The results of our study revealed that the chronic administration of AMC, at a concentration of 100 and 150 mg/kg BW/day, increased capillary n-FGB, and can be associated with a significant increase in the BW and daily water intake in mice.

引用

页码：1229 / 1232

页数：4

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