A protein particle vaccine containing multiple malaria epitopes

被引：133

作者：

Gilbert, SC

Plebanski, M

Harris, SJ

Allsopp, CEM

Thomas, R

Layton, GT

Hill, AVS ^{[1
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Med, Inst Mol Med,Mol Immunol Grp, Oxford OX3 9DU, England

[2] Univ Oxford, Nuffield Dept Med, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

[3] British Biotech Pharmaceut Ltd, Oxford OX4 5LY, England

来源：

NATURE BIOTECHNOLOGY | 1997年 / 15卷 / 12期

基金：

英国惠康基金;

关键词：

vaccine design; antigen presentation;

D O I：

10.1038/nbt1197-1280

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Ty virus-like particles consist of a single protein species that can be produced in yeast. Recombinant Ty-VLPs carrying a string of up to 15 defined cytotoxic T lymphocyte (CTL) epitopes from Plasmodium species prime protective CTL responses in mice following a single administration without adjuvant. Effective processing of epitopes from the string was demonstrated in vitro and in vivo and was not affected by flanking sequences.

引用

页码：1280 / 1284

页数：5

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