Enantiospecific and regioselective rhodium-catalyzed allylic alkylation: Diastereoselective approach to quaternary carbon stereogenic centers

被引：54

作者：

Evans, PA ^{[1
]}

Kennedy, LJ ^{[1
]}

机构：

[1] Univ Delaware, Dept Chem & Biochem, Brown Lab, Newark, DE 19716 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 15期

关键词：

D O I：

10.1021/ol005953g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The enantiospecific and regioselective rhodium-catalyzed allylic alkylation of a series of chiral nonracemic allylic carbonates, followed by ozonolysis and reductive lactonization, provides a convenient route to optically active gamma-lactones, Sequential alkylation and reductive alkylation furnished the alpha-quaternary-beta-ternary substituted gamma-lactone derivative as a greater than or equal to 10:1 mixture of diastereoisomers.

引用

页码：2213 / 2215

页数：3

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