Could Aging Human Skin Use a Connective Tissue Growth Factor Boost to Increase Collagen Content?

被引：32
作者：
Oliver, Noelynn [1 ]
Sternlicht, Mark [1 ]
Gerritsen, Karin [2 ]
Goldschmeding, Roel [1 ,2 ]
机构：
[1] FibroGen Inc, Therapeut Res, San Francisco, CA 94080 USA
[2] Univ Med Ctr Utrecht, Dept Pathol, Utrecht, Netherlands
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2010年 / 130卷 / 02期
关键词：
FACTOR CTGF; EXPRESSION; CYR61; PROGRESSION; ACTIVATION;
D O I：
10.1038/jid.2009.331
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
The roles of connective tissue growth factor ( CTGF) and transforming growth factor-beta (TGF-beta), both well-known collagen production stimulators, were examined in skin aging. Aged skin and fibroblasts exhibited a coordinate decrease in CTGF, TGF-beta, and type I procollagen expression and content. CTGF knockdown and TGF-beta blockade in normal dermal fibroblasts reduced procollagen expression, whereas overexpressing CTGF increased procollagen by a TGF-beta/Smad signaling-dependent mechanism without involving Smad2/3.
引用
收藏
页码：338 / 341
页数：5
相关论文
共 17 条
  • [1] Connective tissue growth factor: growth factor, matricellular organizer, fibrotic biomarker or molecular target for anti-fibrotic therapy in SSc
    Abraham, D.
    [J]. RHEUMATOLOGY, 2008, 47 : V8 - V9
  • [2] Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β
    Abreu, JG
    Ketpura, NI
    Reversade, B
    De Robertis, EM
    [J]. NATURE CELL BIOLOGY, 2002, 4 (08) : 599 - 604
  • [3] Expression of Cyr61, CTGF, and WISP-1 Correlates with Clinical Features of Lung Cancer
    Chen, Ping-Ping
    Li, Wen-Jie
    Wang, Yan
    Zhao, Song
    Li, De-Yun
    Feng, Li-Yun
    Shi, Xiang-Lin
    Koeffler, H. Phillip
    Tong, Xiang-Jun
    Xie, Dong
    [J]. PLOS ONE, 2007, 2 (06):
  • [4] Connective tissue growth factor is secreted through the Golgi and is degraded in the endosome
    Chen, YJ
    Segarini, P
    Raoufi, F
    Bradham, D
    Leask, A
    [J]. EXPERIMENTAL CELL RESEARCH, 2001, 271 (01) : 109 - 117
  • [5] Connective tissue growth factor (CTGF) and cancer progression
    Chu, Chia-Yu
    Chang, Cheng-Chi
    Prakash, Ekambaranellore
    Kuo, Min-Liang
    [J]. JOURNAL OF BIOMEDICAL SCIENCE, 2008, 15 (06) : 675 - 685
  • [6] Connective tissue growth factor: Context-dependent functions and mechanisms of regulation
    Cicha, Iwona
    Goppelt-Struebe, Margarete
    [J]. BIOFACTORS, 2009, 35 (02) : 200 - 208
  • [7] Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases
    Gressner, Olav A.
    Gressner, Axel M.
    [J]. LIVER INTERNATIONAL, 2008, 28 (08) : 1065 - 1079
  • [8] Specific down-regulation of connective tissue growth factor attenuates progression of nephropathy in mouse models of type 1 and type 2 diabetes
    Guha, Mausumee
    Xu, Zhong-Gao
    Tung, David
    Lanting, Linda
    Natarajan, Rama
    [J]. FASEB JOURNAL, 2007, 21 (12) : 3355 - 3368
  • [9] Connective tissue growth factor (CTGF, CCN2) gene regulation: a potent clinical bio-marker of fibroproliferative disease?
    Leask, Andrew
    Parapuram, Sunil K.
    Xu Shi-wen
    Abraham, D. J.
    [J]. JOURNAL OF CELL COMMUNICATION AND SIGNALING, 2009, 3 (02) : 89 - 94
  • [10] Connective tissue growth factor(CCN2), a pathogenic factor in diabetic nephropathy. What does it do? How does it do it?
    Mason, Roger M.
    [J]. JOURNAL OF CELL COMMUNICATION AND SIGNALING, 2009, 3 (02) : 95 - 104
12