Cancer: looking outside the genome

被引：152

作者：

Folkman, J ^{[1
]}

Hahnfeldt, P

Hlatky, L

机构：

[1] Childrens Hosp, Dept Surg, Surg Res Lab, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Dept Radiat Oncol, Boston, MA 02115 USA

[5] Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA 02115 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2000年 / 1卷 / 01期

关键词：

D O I：

10.1038/35036100

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The 'gene-centric' approach has produced a wealth of information about the origins and progression of cancer, and investigators seek a full compilation of altered gene expressions for tumour characterization and treatment. However, the cancer genome appears to be far more unstable than previously thought. It may therefore be prudent to augment gene-level approaches with supra-genomic strategies that circumvent the genomic variability of cancer cells.

引用

页码：76 / 79

页数：4

共 31 条

[1]

[Anonymous], ACCOMPLISHMENTS CANC

[2] DNA hypermethylation in tumorigenesis - epigenetics joins genetics [J].

Baylin, SB ;

Herman, JG .

TRENDS IN GENETICS, 2000, 16 (04) :168-174

[3]

Bissell MJ, 1999, CANCER RES, V59, p1757S

[4] Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance [J].

Boehm, T ;

Folkman, J ;

Browder, T ;

OReilly, MS .

NATURE, 1997, 390 (6658) :404-407

[5]

Browder T, 2000, CANCER RES, V60, P1878

[6] Genetic instability and darwinian selection in tumours (Reprinted from Trends in Biochemical Science, vol 12, Dec., 1999) [J].

Cahill, DP ;

Kinzler, KW ;

Vogelstein, B ;

Lengauer, C .

TRENDS IN CELL BIOLOGY, 1999, 9 (12) :M57-M60

[7]

Feinstein AR, 1997, PERSPECT BIOL MED, V41, P73

[8] Is tissue mass regulated by vascular endothelial cells? Prostate as the first evidence [J].

Folkman, J .

ENDOCRINOLOGY, 1998, 139 (02) :441-442

[9] A TUMOR SUPPRESSOR-DEPENDENT INHIBITOR OF ANGIOGENESIS IS IMMUNOLOGICALLY AND FUNCTIONALLY INDISTINGUISHABLE FROM A FRAGMENT OF THROMBOSPONDIN [J].

GOOD, DJ ;

POLVERINI, PJ ;

RASTINEJAD, F ;

LEBEAU, MM ;

LEMONS, RS ;

FRAZIER, WA ;

BOUCK, NP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (17) :6624-6628

[10]

Hahnfeldt P, 1999, CANCER RES, V59, P4770

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