Cdc42 and Cellular Polarity: Emercing Roles at the Golgi

被引：64

作者：

Farhan, Hesso ^{[1
,2
]}

Hsu, Victor W. ^{[3
,4
]}

机构：

[1] Univ Konstanz, Dept Biol, Constance, Germany

[2] Biotechnol Inst Thurgau, Kreuzlingen, Switzerland

[3] Brigham & Womens Hosp, Div Rheumatol Immunol & Allergy, 75 Francis St, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

来源：

TRENDS IN CELL BIOLOGY | 2016年 / 26卷 / 04期

基金：

瑞士国家科学基金会; 美国国家卫生研究院;

关键词：

LIVING CELLS; SECRETORY PATHWAY; RHO GTPASES; G-PROTEINS; N-WASP; TRANSPORT; MEMBRANE; COMPLEX; LOCALIZATION; ACTIVATION;

D O I：

10.1016/j.tcb.2015.11.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cdc42 belongs to the Rho family of small GTPases and plays key roles in cellular events of polarity. This role of Cdc42 has typically been attributed to its function at the plasma membrane. However, Cdc42 also exists at the Golgi complex. Here we summarize major insights that have been gathered in studying the Golgi pool of Cdc42 and propose that Golgi-localized Cdc42 enables the cell to diversify the function of Cdc42, which in some cases represents new roles and in other cases acts to complement the established roles of Cdc42 at the plasma membrane. Studies on how Cdc42 acts at the Golgi also suggest key questions to address in the future.

引用

页码：241 / 248

页数：8

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