Salt-induced lipid transfer between colloidal supported lipid bilayers

被引:7
作者
Kendall, Eric L. [1 ,2 ]
Mills, Emily [1 ,2 ]
Liu, Juewen [4 ]
Jiang, Xingmao [5 ]
Brinker, C. Jeffrey [3 ,5 ]
Parikh, Atul N. [1 ,2 ]
机构
[1] Univ Calif Davis, Dept Chem Engn & Mat Sci, Davis, CA 95616 USA
[2] Univ Calif Davis, Dept Appl Sci, Davis, CA 95616 USA
[3] Sandia Natl Labs, Albuquerque, NM 87185 USA
[4] Univ Waterloo, Dept Chem, Waterloo, ON N2L 3G1, Canada
[5] Univ New Mexico, Dept Chem Engn, Albuquerque, NM 87131 USA
关键词
PHOSPHOLIPID-VESICLE AGGREGATION; MEMBRANE-FUSION; CELL-ADHESION; MONO-VALENT; FORCES; MECHANISM; RELEASE; CALCIUM; SINGLE; ATTRACTION;
D O I
10.1039/c001586e
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
We show that a coordinated interplay between mesoscale colloidal interactions and molecular-scale membrane perturbations affords a novel material platform to controllably recapitulate membrane interactions, such as during fusion and vesicle-based drug delivery. Specifically, a simple modulation of ionic strength is used to alter electrostatically determined colloidal interactions, producing conditions for pre-fusion contact between two independent colloidal and/or planar supported lipid bilayers. The same process also perturbs the membrane at the molecular level, reproducing conditions needed for subsequent fusion steps. We envisage that this platform will yield insights relevant to optimal design and implementation of lipid-coated inorganic constructs used for therapeutic drug delivery and sensing.
引用
收藏
页码:2628 / 2632
页数:5
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