A Metallomic Approach to Assess Associations of Plasma Metal Levels with Amnestic Mild Cognitive Impairment and Alzheimer's Disease: An Exploratory Study

被引：6

作者：

Lin, Yu-Kai ^{[1
,2
]}

Liang, Chih-Sung ^{[2
,3
]}

Tsai, Chia-Kuang ^{[1
]}

Tsai, Chia-Lin ^{[1
]}

Lee, Jiunn-Tay ^{[1
,2
]}

Sung, Yueh-Feng ^{[1
]}

Chou, Chung-Hsing ^{[1
,2
]}

Shang, Hung-Sheng ^{[4
]}

Yang, Bing-Heng ^{[4
]}

Lin, Guan-Yu ^{[1
,5
]}

Su, Ming-Wei ^{[6
]}

Yang, Fu-Chi ^{[1
,2
]}

机构：

[1] Natl Def Med Ctr, Triserv Gen Hosp, Dept Neurol, Taipei 114, Taiwan

[2] Natl Def Med Ctr, Grad Inst Med Sci, Taipei 114, Taiwan

[3] Natl Def Med Ctr, Triserv Gen Hosp, Dept Psychiat, Beitou Branch, Taipei 112, Taiwan

[4] Natl Def Med Ctr, Dept Pathol, Triserv Gen Hosp, Div Clin Pathol, Taipei 114, Taiwan

[5] Natl Def Med Ctr, Triserv Gen Hosp, Dept Neurol, Songshan Branch, Taipei 105, Taiwan

[6] Acad Sinica, Inst Biomed Sci, Taipei 115, Taiwan

来源：

JOURNAL OF CLINICAL MEDICINE | 2022年 / 11卷 / 13期

关键词：

Alzheimer's disease; mild cognitive impairment; trace metals; biomarkers; in vivo assessment; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; MOUSE MODEL; RECOMMENDATIONS; WORKGROUPS; MANGANESE; DECLINE; MEMORY; BRAIN; RISK;

D O I：

10.3390/jcm11133655

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Alzheimer's disease (AD) involves the abnormal activity of transition metals and metal ion dyshomeostasis; however, the potential of trace metal biomarkers in predicting cognitive decline has not been evaluated. This study aimed to assess the potential of 36 trace elements in predicting cognitive decline in patients with amnestic mild cognitive impairment (aMCI) or AD. Participants (9 controls, 23 aMCI due to AD, and 8 AD dementia) underwent comprehensive cognitive tests, including the Mini-Mental State Examination (MMSE) and trace metal analysis. The correlations between the plasma trace element levels and annual MMSE changes during follow-up were analyzed. We found that an increase in disease severity was linked to lower plasma levels of boron (B), bismuth (Bi), thorium (Th), and uranium (U) (adjusted p < 0.05). Higher baseline calcium levels (r = 0.50, p = 0.026) were associated with less annual cognitive decline; those of B (r = -0.70, p = 0.001), zirconium (r = -0.58, p = 0.007), and Th (r = -0.52, p = 0.020) with rapid annual cognitive decline in the aMCI group; and those of manganese (r = -0.91, p = 0.035) with rapid annual cognitive decline in the AD group. Overall, our exploratory study suggests that plasma metal levels have great potential as in vivo biomarkers for aMCI and AD. Larger sample studies are necessary to confirm these results.

引用

页数：14