Update on primary sclerosing cholangitis

被引：77

作者：

Karlsen, Tom H. ^{[1
]}

Schrumpf, Erik ^{[1
]}

Boberg, Kirsten M. ^{[1
]}

机构：

[1] Univ Oslo, Rikshosp, Oslo Univ Hosp, Norwegian PSC Res Ctr,Med Dept, N-0027 Oslo, Norway

来源：

DIGESTIVE AND LIVER DISEASE | 2010年 / 42卷 / 06期

关键词：

Cholangiocarcinoma; HLA genes; Inflammatory bowel disease; Primary sclerosing cholangitis; DOSE URSODEOXYCHOLIC ACID; INFLAMMATORY-BOWEL-DISEASE; PRIMARY BILIARY-CIRRHOSIS; PREGNANE-X-RECEPTOR; BILE-DUCT STENOSES; MAGNETIC-RESONANCE CHOLANGIOGRAPHY; CONSTITUTIVE ANDROSTANE RECEPTOR; POSITRON-EMISSION-TOMOGRAPHY; CHRONIC ULCERATIVE-COLITIS; GENOME-WIDE ANALYSIS;

D O I：

10.1016/j.dld.2010.01.011

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Early studies in primary sclerosing cholangitis (PSC) were concerned with disease characterization, and were followed by epidemiological studies of PSC and clinical subsets of PSC as well as a large number of treatment trials. Recently, the molecular pathogenesis and the practical handling of the patients have received increasing attention. In the present review we aim to give an update on the pathogenesis of PSC and cholangiocarcinoma in PSC, as well as to discuss the current opinion on diagnosis and treatment of PSC in light of the recent European Association for the Study of the Liver and the American Association for the Study of Liver Diseases practice guidelines. (C) 2010 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

引用

页码：390 / 400

页数：11

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