Synthesis and potential antimetastatic activity of nionovalent and divalent β-D-galactopyranosyl-(l→4)-2-acetamido-2-deoxy-D-glucopyranosides

被引：5

作者：

Li, Q

Su, B

Li, H

Meng, XB

Cai, MS

Li, ZJ ^{[1
]}

Zhou, RL

Suo, TL

机构：

[1] Beijing Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China

[2] Beijing Univ, Sch Basic Med Sci, Dept Cell Biol, Beijing 100083, Peoples R China

来源：

CARBOHYDRATE RESEARCH | 2003年 / 338卷 / 03期

基金：

中国国家自然科学基金;

关键词：

N-acetyllactosamine; monovalent; divalent; synthesis; metastasis;

D O I：

10.1016/S0008-6215(02)00438-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Anomers of monovalent and divalent beta-D-galactopyranosyl-(1-->4)-2-acetamido-2-deoxy-D-gluco-pyranosides were synthesized under different glycosylation conditions, and evaluated for in vitro antimetastatic activity. Three compounds showed promising inhibitory effects on cancer cell attachment, spreading, migration, and invasion. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：207 / 217

页数：11

共 16 条

[11] LI Q, 2001, J PEKING U HLTH SCI, V33, P270
[12] SYNTHESIS OF A TRI-SACCHARIDE AND A HEPTA-SACCHARIDE WHICH CONTAIN ALPHA-L-FUCOPYRANOSYL GROUPS AND ARE PART OF THE COMPLEX TYPE OF CARBOHYDRATE MOIETY OF GLYCOPROTEINS
LONN, H
[J]. CARBOHYDRATE RESEARCH, 1985, 139 (JUN) : 105 - 113
[13] LU YY, 2000, CHINESE J ONCOL, V22, P287
[14] SYNTHESIS OF BETA-GLYCOSIDE BOUND SACCHARIDES OF 2-AMINO-2-DEOXY-D-MANNOSE AND 2-AMINO-2-DEOXY-D-MANNURONIC ACID
PAULSEN, H
LORENTZEN, JP
[J]. CARBOHYDRATE RESEARCH, 1984, 133 (01) : C1 - C4
[15] A CONVENIENT AND HIGHLY CHEMOSELECTIVE METHOD FOR THE REDUCTIVE ACETYLATION OF AZIDES
ROSEN, T
LICO, IM
CHU, DTW
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1988, 53 (07) : 1580 - 1582
[16] YASURO S, 1997, GLYCOBIOLOGY, V7, P1201

← 1 2 →