Synthesis and potential antimetastatic activity of nionovalent and divalent β-D-galactopyranosyl-(l→4)-2-acetamido-2-deoxy-D-glucopyranosides

被引：5

作者：

Li, Q

Su, B

Li, H

Meng, XB

Cai, MS

Li, ZJ ^{[1
]}

Zhou, RL

Suo, TL

机构：

[1] Beijing Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China

[2] Beijing Univ, Sch Basic Med Sci, Dept Cell Biol, Beijing 100083, Peoples R China

来源：

CARBOHYDRATE RESEARCH | 2003年 / 338卷 / 03期

基金：

中国国家自然科学基金;

关键词：

N-acetyllactosamine; monovalent; divalent; synthesis; metastasis;

D O I：

10.1016/S0008-6215(02)00438-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Anomers of monovalent and divalent beta-D-galactopyranosyl-(1-->4)-2-acetamido-2-deoxy-D-gluco-pyranosides were synthesized under different glycosylation conditions, and evaluated for in vitro antimetastatic activity. Three compounds showed promising inhibitory effects on cancer cell attachment, spreading, migration, and invasion. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：207 / 217

页数：11

共 16 条

[1] ALBINI A, 1987, CANCER RES, V47, P3239
[2] SYNTHESIS OF A TRI-SACCHARIDE, A PENTA-SACCHARIDE, AND A HEPTA-SACCHARIDE CONTAINING TERMINAL N-ACETYL-BETA-D-LACTOSAMINYL RESIDUES, PART OF THE COMPLEX-TYPE CARBOHYDRATE MOIETY OF GLYCOPROTEINS
ARNARP, J
LONNGREN, J
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1981, (07): : 2070 - 2074
[3] STRUCTURES OF THE ASPARAGINE-LINKED SUGAR CHAINS OF LAMININ
ARUMUGHAM, RG
HSIEH, TCY
TANZER, ML
LAINE, RA
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1986, 883 (01) : 112 - 126
[4] CHEN XQ, 1998, AIZHENG, V17, P477
[5] SYNTHESES OF THE METHYL GLYCOSIDES OF THE REPEATING UNITS OF CHONDROITIN 4-SULFATE AND 6-SULFATE
JACQUINET, JC
[J]. CARBOHYDRATE RESEARCH, 1990, 199 (02) : 153 - 181
[6] GLYCOSYLIMIDATES .24. APPLICATION OF THE TRICHLOROACETIMIDATE METHOD TO THE SYNTHESIS OF GLYCOPEPTIDES OF THE MUCIN TYPE CONTAINING A BETA-D-GALP-(1-]3)-D-GALPNAC UNIT
KINZY, W
SCHMIDT, RR
[J]. CARBOHYDRATE RESEARCH, 1987, 164 : 265 - 276
[7] CHEMICAL SYNTHESIS OF 2-O-(ALPHA-L-FUCOPYRANOSYL)-3-O-(ALPHA-D-GALACTOPYRANOSYL)-D-GALACTOSE- TERMINAL STRUCTURE OF BLOOD-GROUP-B ANTIGENIC DETERMINANT
LEMIEUX, RU
DRIGUEZ, H
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1975, 97 (14) : 4069 - 4075
[8] AZIDONITRATION OF TRI-O-ACETYL-D-GALACTAL
LEMIEUX, RU
RATCLIFFE, RM
[J]. CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1979, 57 (10): : 1244 - 1251
[9] CHEMICAL SYNTHESIS OF 2-ACETAMIDO-2-DEOXY-4-O-(ALPHA-L-FUCOPYRANOSYL)-3-O-(BETA-D-GALACTOPYRANOSYL)-D-GLUCOSE - LEWIS A BLOOD-GROUP ANTIGENIC DETERMINANT
LEMIEUX, RU
DRIGUEZ, H
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1975, 97 (14) : 4063 - 4069
[10] Studies on carbohydrates.: Part 33:: Synthesis of spacer-armed 2-acetamido-2-deoxy-4-O-β-D-galactopyranosyl-α-D-mannosides and their dimers
Li, Q
Li, H
Cai, MS
Li, ZJ
Zhou, RL
[J]. TETRAHEDRON-ASYMMETRY, 1999, 10 (14) : 2675 - 2683

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