Age and Parkinson's Disease-Related Neuronal Death in the Substantia Nigra Pars Compacta

被引：23

作者：

Eriksen, Nina ^{[1
]}

Stark, Anette Kirstine ^{[1
]}

Pakkenberg, Bente ^{[1
]}

机构：

[1] Copenhagen Univ Hosp Bispebjerg, Res Lab Stereol & Neurosci, Copenhagen, Denmark

来源：

JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT | 2009年 / 73期

关键词：

Aging; Dopaminergic neurons; Parkinson's disease; Substantia nigra pars compacta; FIBROBLAST-GROWTH-FACTOR; DOPAMINERGIC-NEURONS; ALPHA-SYNUCLEIN; HUMAN-BRAIN; CELL-DEATH; IMMUNOREACTIVE NEURONS; NIGROSTRIATAL SYSTEM; HISTOLOGICAL-CHANGES; DEPENDENT DECLINE; BINDING-SITES;

D O I：

10.1007/978-3-211-92660-4_16

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

During aging, decline in memory and cognitive abilities as well as motor weakening is of great concern. The dopaminergic system mediates some aspects of manual dexterity, in addition to cognition and emotion, and may be especially vulnerable to aging. A common neurodegenerative disorder of this system, Parkinson's disease, is characterized by a selective, progressive loss of dopaminergic neurons in the substantia nigra pars compacta. This review includes studies quantifying age and Parkinson's-related changes of the substantia nigra, with emphasis on stereological studies performed in the substantia nigra pars compacta.

引用

页码：203 / 213

页数：11

共 112 条

[81] A STEREOLOGICAL STUDY OF SUBSTANTIA-NIGRA IN YOUNG AND OLD RHESUS-MONKEYS [J].

PAKKENBERG, H ;

ANDERSEN, BB ;

BURNS, RS ;

PAKKENBERG, B .

BRAIN RESEARCH, 1995, 693 (1-2) :201-206

[82] Practical approaches to stereology in the setting of aging- and disease-related brain banks [J].

Perl, DP ;

Good, PF ;

Bussière, T ;

Morrison, JH ;

Erwin, JM ;

Hof, PR .

JOURNAL OF CHEMICAL NEUROANATOMY, 2000, 20 (01) :7-19

[83] Ageing and the nigrostriatal dopaminergic system [J].

Reeves, S ;

Bench, C ;

Howard, R .

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 2002, 17 (04) :359-370

[84] DECREASE IN HUMAN STRIATAL DOPAMINE-D2 RECEPTOR DENSITY WITH AGE - A PET STUDY WITH [C-11] RACLOPRIDE [J].

RINNE, JO ;

HIETALA, J ;

RUOTSALAINEN, U ;

SAKO, E ;

LAIHINEN, A ;

NAGREN, K ;

LEHIKOINEN, P ;

OIKONEN, V ;

SYVALAHTI, E .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1993, 13 (02) :310-314

[85] AGE-DEPENDENT DECLINE IN HUMAN BRAIN DOPAMINE-D1 AND DOPAMINE-D2 RECEPTORS [J].

RINNE, JO ;

LONNBERG, P ;

MARJAMAKI, P .

BRAIN RESEARCH, 1990, 508 (02) :349-352

[86] MUSCARINIC AND DOPAMINERGIC RECEPTORS IN THE AGING HUMAN-BRAIN [J].

RINNE, JO .

BRAIN RESEARCH, 1987, 404 (1-2) :162-168

[87] Morphometry of the human substantia nigra in ageing and Parkinson's disease [J].

Rudow, Gay ;

O'Brien, Richard ;

Savonenko, Alena V. ;

Resnick, Susan M. ;

Zonderman, Alan B. ;

Pletnikova, Olga ;

Marsh, Laura ;

Dawson, Ted M. ;

Crain, Barbara J. ;

West, Mark J. ;

Troncoso, Juan C. .

ACTA NEUROPATHOLOGICA, 2008, 115 (04) :461-470

[88] SELECTIVE LOSS OF SUBPOPULATIONS OF VENTRAL MESENCEPHALIC DOPAMINERGIC-NEURONS IN THE MONKEY FOLLOWING EXPOSURE TO MPTP [J].

SCHNEIDER, JS ;

YUWILER, A ;

MARKHAM, CH .

BRAIN RESEARCH, 1987, 411 (01) :144-150

[89] HUMAN-BRAIN DOPAMINE-RECEPTORS IN CHILDREN AND AGING ADULTS [J].

SEEMAN, P ;

BZOWEJ, NH ;

GUAN, HC ;

BERGERON, C ;

BECKER, LE ;

REYNOLDS, GP ;

BIRD, ED ;

RIEDERER, P ;

JELLINGER, K ;

WATANABE, S ;

TOURTELLOTTE, WW .

SYNAPSE, 1987, 1 (05) :399-404

[90] AGE-CORRELATED LOSS OF DOPAMINERGIC BINDING-SITES IN HUMAN BASAL GANGLIA [J].

SEVERSON, JA ;

MARCUSSON, J ;

WINBLAD, B ;

FINCH, CE .

JOURNAL OF NEUROCHEMISTRY, 1982, 39 (06) :1623-1631

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