Age and Parkinson's Disease-Related Neuronal Death in the Substantia Nigra Pars Compacta

被引：23
作者：
Eriksen, Nina [1 ]
Stark, Anette Kirstine [1 ]
Pakkenberg, Bente [1 ]
机构：
[1] Copenhagen Univ Hosp Bispebjerg, Res Lab Stereol & Neurosci, Copenhagen, Denmark
来源：
JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT | 2009年 / 73期
关键词：
Aging; Dopaminergic neurons; Parkinson's disease; Substantia nigra pars compacta; FIBROBLAST-GROWTH-FACTOR; DOPAMINERGIC-NEURONS; ALPHA-SYNUCLEIN; HUMAN-BRAIN; CELL-DEATH; IMMUNOREACTIVE NEURONS; NIGROSTRIATAL SYSTEM; HISTOLOGICAL-CHANGES; DEPENDENT DECLINE; BINDING-SITES;
D O I：
10.1007/978-3-211-92660-4_16
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
During aging, decline in memory and cognitive abilities as well as motor weakening is of great concern. The dopaminergic system mediates some aspects of manual dexterity, in addition to cognition and emotion, and may be especially vulnerable to aging. A common neurodegenerative disorder of this system, Parkinson's disease, is characterized by a selective, progressive loss of dopaminergic neurons in the substantia nigra pars compacta. This review includes studies quantifying age and Parkinson's-related changes of the substantia nigra, with emphasis on stereological studies performed in the substantia nigra pars compacta.
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收藏
页码：203 / 213
页数：11
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