Age and Parkinson's Disease-Related Neuronal Death in the Substantia Nigra Pars Compacta

被引：23

作者：

Eriksen, Nina ^{[1
]}

Stark, Anette Kirstine ^{[1
]}

Pakkenberg, Bente ^{[1
]}

机构：

[1] Copenhagen Univ Hosp Bispebjerg, Res Lab Stereol & Neurosci, Copenhagen, Denmark

来源：

JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT | 2009年 / 73期

关键词：

Aging; Dopaminergic neurons; Parkinson's disease; Substantia nigra pars compacta; FIBROBLAST-GROWTH-FACTOR; DOPAMINERGIC-NEURONS; ALPHA-SYNUCLEIN; HUMAN-BRAIN; CELL-DEATH; IMMUNOREACTIVE NEURONS; NIGROSTRIATAL SYSTEM; HISTOLOGICAL-CHANGES; DEPENDENT DECLINE; BINDING-SITES;

D O I：

10.1007/978-3-211-92660-4_16

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

During aging, decline in memory and cognitive abilities as well as motor weakening is of great concern. The dopaminergic system mediates some aspects of manual dexterity, in addition to cognition and emotion, and may be especially vulnerable to aging. A common neurodegenerative disorder of this system, Parkinson's disease, is characterized by a selective, progressive loss of dopaminergic neurons in the substantia nigra pars compacta. This review includes studies quantifying age and Parkinson's-related changes of the substantia nigra, with emphasis on stereological studies performed in the substantia nigra pars compacta.

引用

页码：203 / 213

页数：11

共 112 条

[1] Risk of dementia in Parkinson's disease - A community-based, prospective study [J].

Aarsland, D ;

Andersen, K ;

Larsen, JP ;

Lolk, A ;

Nielsen, H ;

Kragh-Sorensen, P .

NEUROLOGY, 2001, 56 (06) :730-736

[2] Group I mGluR antagonist AIDA protects nigral DA cells from MPTP-induced injury [J].

Aguirre, JA ;

Andbjer, B ;

González-Barón, S ;

Hansson, A ;

Strömberg, I ;

Agnati, LF ;

Fuxe, K .

NEUROREPORT, 2001, 12 (12) :2615-2617

[3]

Anglade P, 1997, HISTOL HISTOPATHOL, V12, P603

[4] DOPAMINE D2 RECEPTORS IN NORMAL HUMAN BRAIN - EFFECT OF AGE MEASURED BY POSITRON EMISSION TOMOGRAPHY (PET) AND [C-11] RACLOPRIDE [J].

ANTONINI, A ;

LEENDERS, KL .

ALZHEIMERS DISEASE: AMYLOID PRECUSOR PROTEINS, SIGNAL TRANSDUCTION, AND NEURONAL TRANSPLANTATION, 1993, 695 :81-85

[5] Brain monoaminergic and neuropeptidergic variations in human aging [J].

Arranz, B ;

Blennow, K ;

Ekman, R ;

Eriksson, A ;

Mansson, JE ;

Marcusson, J .

JOURNAL OF NEURAL TRANSMISSION, 1996, 103 (1-2) :101-115

[6] DOPAMINE TRANSPORTER MESSENGER-RNA CONTENT IN HUMAN SUBSTANTIA-NIGRA DECREASES PRECIPITOUSLY WITH AGE [J].

BANNON, MJ ;

POOSCH, MS ;

YUE, X ;

GOEBEL, DJ ;

CASSIN, B ;

KAPATOS, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (15) :7095-7099

[7] Evidence of active microglia in substantia nigra pars compacta of parkinsonian monkeys 1 year after MPTP exposure [J].

Barcia, C ;

Bahillo, AS ;

Fernández-Villalba, E ;

Bautista, V ;

Poza, MPY ;

Fernández-Barreiro, A ;

Hirsch, EC ;

Herrero, MT .

GLIA, 2004, 46 (04) :402-409

[8] Analysis of Gene Expression in Parkinson's Disease: Possible Involvement of Neurotrophic Support and Axon Guidance in Dopaminergic Cell Death [J].

Bossers, Koen ;

Meerhoff, Gideon ;

Balesar, Rawien ;

van Dongen, Jeroen W. ;

Kruse, Chris G. ;

Swaab, Dick F. ;

Verhaagen, Joost .

BRAIN PATHOLOGY, 2009, 19 (01) :91-107

[9] PIGMENTOARCHITECTONIC PATHOLOGY OF THE ISOCORTEX IN JUVENILE NEURONAL CEROID-LIPOFUSCINOSIS - AXONAL ENLARGEMENTS IN LAYER-IIIAB AND CELL LOSS IN LAYER-V [J].

BRAAK, H ;

GOEBEL, HH .

ACTA NEUROPATHOLOGICA, 1979, 46 (1-2) :79-83

[10] Staging of brain pathology related to sporadic Parkinson's disease [J].

Braak, H ;

Del Tredici, K ;

Rüb, U ;

de Vos, RAI ;

Steur, ENHJ ;

Braak, E .

NEUROBIOLOGY OF AGING, 2003, 24 (02) :197-211

← 1 2 3 4 5 6 7 8 9 10 →