Water-soluble AIE-Active Fluorescent Organic Nanoparticles: Design, Preparation and Application for Specific Detection of Cysteine over Homocysteine and Glutathione in Living Cells

被引：27

作者：

Ning, Zhang-wei ^{[1
]}

Wu, Song-ze ^{[2
]}

Liu, Guang-jian ^{[1
]}

Ji, Yan-ming ^{[1
]}

Jia, Li-yan ^{[1
]}

Niu, Xiao-xiao ^{[1
]}

Ma, Rong-fang ^{[1
]}

Zhang, Yuan ^{[1
,3
]}

Xing, Guo-wen ^{[1
]}

机构：

[1] Beijing Normal Univ, Coll Chem, Beijing 100875, Peoples R China

[2] Renmin Univ China, High Sch, Beijing 100080, Peoples R China

[3] Beijing Normal Univ, Coll Chem, Key Lab Energy Convers & Storage Mat, Beijing 100875, Peoples R China

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2019年 / 14卷 / 13期

基金：

北京市自然科学基金; 国家重点研发计划;

关键词：

aggregation-induced emission; biothiols; cysteine; nanoparticles; tetraphenylethylene; PLASMA HOMOCYSTEINE; PROBES; THIOLS;

D O I：

10.1002/asia.201900551

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Water-soluble ratiometric AIE-active fluorescent organic nanoparticles 2OA-FON for the specific sensing of cysteine over other biothiols are reported. The obtained amphiphilic probe included olefin aldehyde as recognizing unit, tetraphenylethylene as fluorescence reporter and lactose moiety as a hydrophilic group. This work provides a general design strategy based on the introduction of a sugar moiety into a hydrophobic AIEgen to develop ratiometric water-soluble fluorescent organic nanoparticles.

引用

页码：2220 / 2224

页数：5

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