Expedient, one-pot preparation of fused indoles via CAN-catalyzed three-component domino sequences and their transformation into polyheterocyclic compounds containing pyrrolo[1,2-a]azepine fragments

被引：50

作者：

Suryavanshi, Padmakar A. ^{[1
]}

Sridharan, Vellaisamy ^{[1
]}

Carlos Menendez, J. ^{[1
]}

机构：

[1] Univ Complutense, Fac Farm, Dept Quim Organ & Farmaceut, E-28040 Madrid, Spain

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2010年 / 8卷 / 15期

关键词：

CERIUM(IV) AMMONIUM-NITRATE; RING-CLOSING METATHESIS; NONREARRANGED MONOTERPENOID UNIT; NENITZESCU REACTION; MULTICOMPONENT REACTIONS; PRIVILEGED STRUCTURES; HUMAN; 5-LIPOXYGENASE; MEDICINAL CHEMISTRY; NATURAL-PRODUCTS; DRUG DISCOVERY;

D O I：

10.1039/c004703a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The CAN-catalyzed three-component between reaction between primary amines, beta-dicarbonyl compounds and naphthoquinones or 2-bromonaphthoquinones afforded, respectively, 5-hydroxybenzo[g]indoles and benzo[f]indole-4,9-diones, the former of which were transformed into tetracyclic azepino[1,2-a]benzo[g]indole systems through a gamma-alkylation/ring-closing metathesis sequence.

引用

页码：3426 / 3436

页数：11

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