Acetate/acetyl-CoA metabolism associated with cancer fatty acid synthesis: Overview and application

被引：78
作者：
Yoshii, Yukie [1 ]
Furukawa, Takako [1 ]
Saga, Tsuneo [1 ]
Fujibayashi, Yasuhisa [1 ]
机构：
[1] Natl Inst Radiol Sci, Mol Imaging Ctr, Anagawa, Chiba 2638555, Japan
来源：
CANCER LETTERS | 2015年 / 356卷 / 02期
关键词：
Acetate; Acetyl CoA; Fatty acid; Positron emission tomography; Metabolism; COENZYME-A SYNTHETASE; POSITRON-EMISSION-TOMOGRAPHY; ATP CITRATE LYASE; ACETYL-COENZYME; OXYGEN-CONSUMPTION; PROSTATE-CANCER; SACCHAROMYCES-CEREVISIAE; SYNTHASE GENE; CELL-SURVIVAL; C-11; ACETATE;
D O I：
10.1016/j.canlet.2014.02.019
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Understanding cancer-specific metabolism is important for identifying novel targets for cancer diagnosis and therapy. Induced acetate/acetyl CoA metabolism is a notable feature that is related to fatty acid synthesis supporting tumor growth. In this review, we focused on the recent findings related to cancer acetate/acetyl CoA metabolism. We also introduce [1-C-11]acetate positron emission tomography (PET), which is a useful tool to visualize up-regulation of acetate/acetyl CoA metabolism in cancer, and discuss the utility of [1:C-11]acetate PET in cancer diagnosis and its application to personalized medicine. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：211 / 216
页数：6
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