Respiratory ATP synthesis: the new generation of mycobacterial drug targets?

被引：74

作者：

Bald, Dirk ^{[1
]}

Koul, Anil ^{[2
]}

机构：

[1] Vrije Univ Amsterdam, Dept Mol Cell Biol, Fac Earth & Life Sci, NL-1081 HV Amsterdam, Netherlands

[2] Tibotec NV, Dept Antimicrobial Res, Johnson & Johnson Pharmaceut Res & Dev, Beerse, Belgium

来源：

FEMS MICROBIOLOGY LETTERS | 2010年 / 308卷 / 01期

关键词：

mycobacteria; ATP synthesis; respiratory chain; dormancy; antimycobacterial drugs; MULTIDRUG-RESISTANT TUBERCULOSIS; ESCHERICHIA-COLI; IN-VITRO; SYNTHASE; SUBUNIT; R207910; GROWTH; OXIDOREDUCTASE; SMEGMATIS; MECHANISM;

D O I：

10.1111/j.1574-6968.2010.01959.x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mycobacterium tuberculosis, the causative agent of tuberculosis, poses a global health challenge due to the emergence of drug-resistant strains. Recently, bacterial energy metabolism has come into focus as a promising new target pathway for the development of antimycobacterial drugs. This review summarizes our current knowledge on mycobacterial respiratory energy conversion, in particular, during the physiologically dormant state that is associated with latent or persistent tuberculosis infections. Targeting components of respiratory ATP production, such as type-2 NADH dehydrogenase or ATP synthase, is illustrated as an emerging strategy in the development of novel drugs.

引用

页码：1 / 7

页数：7

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