Borrelidins C-E: New Antibacterial Macrolides from a Saltern-Derived Halophilic Nocardiopsis sp.

被引：40

作者：

Kim, Jungwoo ^{[1
]}

Shin, Daniel ^{[1
]}

Kim, Seong-Hwan ^{[1
]}

Park, Wanki ^{[2
]}

Shin, Yoonho ^{[1
]}

Kim, Won Kyung ^{[1
]}

Lee, Sang Kook ^{[1
]}

Oh, Ki-Bong ^{[2
]}

Shin, Jongheon ^{[1
]}

Oh, Dong-Chan ^{[1
]}

机构：

[1] Seoul Natl Univ, Nat Prod Res Inst, Coll Pharm, Seoul 08826, South Korea

[2] Seoul Natl Univ, Dept Agr Biotechnol, Coll Agr & Life Sci, Seoul 08826, South Korea

来源：

MARINE DRUGS | 2017年 / 15卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

antibacterial; saltern; halophilic actinomycetes; borrelidin; Salmonella enterica; ACTINOMYCETE; DISCOVERY;

D O I：

10.3390/md15060166

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chemical investigation of a halophilic actinomycete strain belonging to the genus Nocardiopsis inhabiting a hypersaline saltern led to the discovery of new 18-membered macrolides with nitrile functionality, borrelidins C-E (1-3), along with a previously reported borrelidin (4). The planar structures of borrelidins C-E, which are new members of the rare borrelidin class of antibiotics, were elucidated by NMR, mass, IR, and UV spectroscopic analyses. The configurations of borrelidines C-E were determined by the interpretation of ROESY NMR spectra, J-based configuration analysis, a modified Mosher's method, and CD spectroscopic analysis. Borrelidins C and D displayed inhibitory activity, particularly against the Gram-negative pathogen Salmonella enterica, and moderate cytotoxicity against the SNU638 and K562 carcinoma cell lines.

引用

页数：11

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