Aspergillus flavus:: human pathogen, allergen and mycotoxin producer

被引:626
作者
Hedayati, M. T.
Pasqualotto, A. C.
Warn, P. A.
Bowyer, P.
Denning, D. W.
机构
[1] Univ Manchester, Sch Med, Manchester M23 9PL, Lancs, England
[2] Wythenshawe Hosp, Manchester M23 9PL, Lancs, England
[3] Mazandaran Univ Med Sci, Sch Med, Dept Med Mycol & Parasitol, Sari, Iran
来源
MICROBIOLOGY-SGM | 2007年 / 153卷
关键词
D O I
10.1099/mic.0.2007/007641-0
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Aspergillus infections have grown in importance in the last years. However, most of the studies have focused on Aspergillus fumigatus, the most prevalent species in the genus. In certain locales and hospitals, Aspergillus flavus is more common in air than A. fumigatus, for unclear reasons. After A. fumigatus, A. flavus is the second leading cause of invasive aspergillosis and it is the most common cause of superficial infection. Experimental invasive infections in mice show A. flavus to be 100-fold more virulent than A. fumigatus in terms of inoculum required. Particularly common clinical syndromes associated with A. flavus include chronic granulonnatous sinusitis, keratitis, cutaneous aspergillosis, wound infections and osteomyelitis following trauma and inoculation. Outbreaks associated with A. flavus appear to be associated with single or closely related strains, in contrast to those associated with A. fumigatus. In addition, A. flavus produces aflatoxins, the most toxic and potent hepatocarcinogenic natural compounds ever characterized. Accurate species identification within Aspergillus flavus complex remains difficult due to overlapping morphological and biochemical characteristics, and much taxonomic and population genetics work is necessary to better understand the species and related species. The flavus complex currently includes 23 species or varieties, including two sexual species, Petromyces alliaceus and P. albertensis. The genome of the highly related Aspergillus oryzae is completed and available; that of A. flavus in the final stages of annotation. Our understanding of A. flavus lags far behind that of A. fumigatus. Studies of the genomics, taxonomy, population genetics, pathogenicity, allergenicity and antifungal susceptibility of A. flavus are all required.
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页码:1677 / 1692
页数:16
相关论文
共 178 条
[2]  
ACQUATI F, 1987, Giornale Italiano di Cardiologia, V17, P467
[3]   Air-borne viable, non-viable, and allergenic fungi in a rural agricultural area of India: a 2-year study at five outdoor sampling stations [J].
Adhikari, A ;
Sen, MM ;
Gupta-Bhattacharya, S ;
Chanda, S .
SCIENCE OF THE TOTAL ENVIRONMENT, 2004, 326 (1-3) :123-141
[4]   ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS DUE TO ASPERGILLUS-ORYZAE [J].
AKIYAMA, K ;
TAKIZAWA, H ;
SUZUKI, M ;
MIYACHI, S ;
ICHINOHE, M ;
YANAGIHARA, Y .
CHEST, 1987, 91 (02) :285-286
[5]   PRIMARY CUTANEOUS ASPERGILLOSIS ASSOCIATED WITH HICKMAN INTRAVENOUS CATHETERS [J].
ALLO, MD ;
MILLER, J ;
TOWNSEND, T ;
TAN, C .
NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (18) :1105-1108
[6]   Chronic invasive aspergillosis of the paranasal sinuses in immunocompetent hosts from Saudi Arabia [J].
Alrajhi, AA ;
Enani, M ;
Mahasin, Z ;
Al-Omran, K .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2001, 65 (01) :83-86
[7]   Pathogenic Aspergillus species recovered from a hospital water system:: A 3-year prospective study [J].
Anaissie, EJ ;
Stratton, SL ;
Dignani, MC ;
Summerbell, RC ;
Rex, JH ;
Monson, TP ;
Spencer, T ;
Kasai, M ;
Francesconi, A ;
Walsh, TJ .
CLINICAL INFECTIOUS DISEASES, 2002, 34 (06) :780-789
[8]   4 NEW SPECIES OF ASPERGILLUS FROM IVORY COAST SOIL [J].
BARTOLI, A ;
MAGGI, O .
TRANSACTIONS OF THE BRITISH MYCOLOGICAL SOCIETY, 1978, 71 (DEC) :383-394
[9]  
BATISTA AC, 1955, AN SOC BIOL PERNAMB, V8, P94
[10]   Ochratoxin production by the Aspergillus ochraceus group and Aspergillus alliaceus [J].
Bayman, P ;
Baker, JL ;
Doster, MA ;
Michailides, TJ ;
Mahoney, NE .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2002, 68 (05) :2326-2329