Hydrogen sulfide inhibits human platelet aggregation

被引：92
作者：
Zagli, Giovanni
Patacchini, Riccardo
Trevisani, Marcello
Abbate, Rosanna
Cinotti, Sandro
Gensini, Gian Franco
masotti, Giulio
Geppetti, Pierangelo
机构：
[1] Univ Florence, Dept Crit Care Med & Surg, Florence, Italy
[2] Chiesi Pharmaceut, Dept Pharmacol, Parma, Italy
[3] Univ Ferrara, Dept Expt Med & Clin Med, Pharmacol Unit, I-44100 Ferrara, Italy
[4] Univ Careggi, Hemophila Ctr, Azienda Osped, Florence, Italy
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2007年 / 559卷 / 01期
关键词：
hydrogen sulfide; H2S; platelet inhibition; thromboembolic disease; cardiovascular risk factor;
D O I：
10.1016/j.ejphar.2006.12.011
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Gaseous mediators such as nitric oxide (NO) play a major regulatory role in the cardiovascular system homeostasis, including platelet aggregation. Here, we investigated whether hydrogen sulfide (H-S), a newly recognized endogenous mediator, can affects aggregation of human platelets, using sodium hydrogen sulfide (NaHS) as H,S-donor. NaHS inhibited platelet aggregation induced by ADP, collagen, epinephrine, arachidonic acid, thromboxane mimetic, U46619, and thrombin. H,S effect was not dependent by cAMP/cGMP generation, NO production or potassium-channels opening. NaHS concentrations (up to 10 mM) did not exert toxic effects on platelet viability. The possible protective role of endogenous H2S in cardiovascular system is discussed. (c) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码：65 / 68
页数：4
相关论文
共 20 条
[1]   A CRITICAL-REVIEW OF THE LITERATURE ON HYDROGEN-SULFIDE TOXICITY [J].
BEAUCHAMP, RO ;
BUS, JS ;
POPP, JA ;
BOREIKO, CJ ;
ANDJELKOVICH, DA .
CRC CRITICAL REVIEWS IN TOXICOLOGY, 1984, 13 (01) :25-97
[2]   THE INFLUENCE OF SULFIDE AND CYANIDE ON AXONAL FUNCTION [J].
BECK, JF ;
DONINI, JC ;
MANECKJEE, A .
TOXICOLOGY, 1983, 26 (01) :37-45
[3]  
Belardinelli MC, 2001, CLIN CHEM, V47, P1500
[4]   Role of hydrogen sulfide in the cardioprotection caused by ischemic preconditioning in the rat heart and cardiac myocytes [J].
Bian, JS ;
Yong, QC ;
Pan, TT ;
Feng, ZN ;
Ali, MY ;
Zhou, SF ;
Moore, PK .
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2006, 316 (02) :670-678
[5]   AGGREGATION OF BLOOD PLATELETS BY ADENOSINE DIPHOSPHATE AND ITS REVERSAL [J].
BORN, GVR .
NATURE, 1962, 194 (4832) :927-&
[6]   Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia [J].
Collin, M ;
Anuar, FBM ;
Murch, O ;
Bhatia, M ;
Moore, PK ;
Thiemermann, C .
BRITISH JOURNAL OF PHARMACOLOGY, 2005, 146 (04) :498-505
[7]   The role of thiols and disulfides in platelet function [J].
Essex, DW .
ANTIOXIDANTS & REDOX SIGNALING, 2004, 6 (04) :736-746
[8]   A novel enhancing mechanism for hydrogen sulfide-producing activity of cystathionine β-synthase [J].
Eto, K ;
Kimura, H .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (45) :42680-42685
[9]  
Ho Paul C, 2003, Int J Cardiovasc Intervent, V5, P95
[10]   The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide [J].
Hosoki, R ;
Matsuki, N ;
Kimura, H .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 237 (03) :527-531
12