Cadmium(II) complex with 2-methyl-1H-4,5-imidazoledicarboxylic acid ligand: synthesis, characterization, and biological activity

被引：11

作者：

Ma, Chi ^{[1
]}

Liang, Shi-Kai ^{[1
]}

Zhao, Fu-Chen ^{[1
]}

Meng, Yang ^{[1
]}

Li, Ying-Ying ^{[1
]}

Zhu, Ming-Chang ^{[1
]}

Gao, En-Jun ^{[1
]}

机构：

[1] Shenyang Univ Chem Technol, Dept Coordinat Chem, Int Key Lab Shenyang Inorgan Mol Based Chem, Shenyang, Peoples R China

来源：

JOURNAL OF COORDINATION CHEMISTRY | 2014年 / 67卷 / 21期

关键词：

Cd(II) complex; DNA binding; Biological activity; DNA-BINDING; PLATINUM(II) COMPLEXES; SPECTRAL PROPERTIES; ANTITUMOR AGENTS; POLYPYRIDYL COMPLEXES; ANTICANCER ACTIVITY; ORGANIC FRAMEWORKS; CRYSTAL-STRUCTURES; CD(II) COMPLEXES; HYDROGEN-BOND;

D O I：

10.1080/00958972.2014.970540

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Complex binding to DNA in an intercalative mode A coordination polymer, [Cd(L)(2)(H2O)(2)](n) (HL = 2-methyl-1H-4,5-imidazoledicarboxylic acid), was prepared from reactions of Cd(NO3)(2) with L at room temperature. It was characterized by IR spectra and elemental analysis. The complex was structurally characterized by X-ray single-crystal diffraction revealing that the complex crystallizes in monoclinic with P2(1)/c space group, a = 12.203(10) angstrom, b = 9.332(8) angstrom, c = 7.554(7) angstrom, beta = 100.894(2) angstrom, V = 844.7(13) angstrom(3), Z = 2. Fluorescence and UV absorption spectroscopy indicated that the complex can bind to fish sperm DNA. Gel electrophoresis assay demonstrated the ability to cleave the HL-60 plasmid DNA. Apoptotic study showed that the complex exhibited significant cancer cell (JEKO and KB) inhibitory rate.

引用

页码：3551 / 3564

页数：14

共 59 条

[1]

ALLEY MC, 1988, CANCER RES, V48, P589

[2] A comparative study of calf thymus DNA binding to Cr(III) and Cr(VI) ions - Evidence for the guanine N-7-chromium-phosphate chelate formation [J].

Arakawa, H ;

Ahmad, R ;

Naoui, M ;

Tajmir-Riahi, HA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (14) :10150-10153

[3] QUENCHING OF DNA-ETHIDIUM FLUORESCENCE BY AMSACRINE AND OTHER ANTITUMOR AGENTS - A POSSIBLE ELECTRON-TRANSFER EFFECT [J].

BAGULEY, BC ;

LEBRET, M .

BIOCHEMISTRY, 1984, 23 (05) :937-943

[4] Luminescent pH sensing and DNA binding properties of a novel ruthenium(II) complex [J].

Bai, GY ;

Wang, KZ ;

Duan, ZM ;

Gao, LH .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2004, 98 (06) :1017-1022

[5] INDUCED OPTICAL ACTIVITY OF VAROIUS AMINOACRIDINES BOUND TO DNA [J].

BLAKE, A ;

PEACOCKE, AR .

BIOPOLYMERS, 1967, 5 (09) :871-&

[6]

Brandenburg K., 2006, DIAMOND

[7] Synthesis, characterization, DNA-binding and spectral properties of complexes [Ru(L)4(dppz)]2+ (L = Im and MeIm) [J].

Chen, Lan-Mei ;

Liu, Jie ;

Chen, Jin-Can ;

Tan, Cai-Ping ;

Shi, Shuo ;

Zheng, Kang-Cheng ;

Ji, Liang-Nian .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2008, 102 (02) :330-341

[8] Late transition metal complexes of a new P-N ligand Ph2PCH2N(H)C5H3(Cl-5)N:: synthesis and structural studies [J].

Coles, SJ ;

Durran, SE ;

Hursthouse, MB ;

Slawin, AMZ ;

Smith, MB .

NEW JOURNAL OF CHEMISTRY, 2001, 25 (03) :416-422

[9] Recent developments in the field of supramolecular lanthanide luminescent sensors and self-assemblies [J].

dos Santos, Cidalia M. G. ;

Harte, Andrew J. ;

Quinn, Susan J. ;

Gunnlaugsson, Thorfinnur .

COORDINATION CHEMISTRY REVIEWS, 2008, 252 (23-24) :2512-2527

[10]

Gao EJ, 2004, ACTA CHIM SINICA, V62, P593

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