Pregnancy after treatment of secondary acute promyelocytic leukemia following Hodgkin's disease: a case report

The authors report a case of therapy-related acute promyelocytic leukemia (t-APL), with typical cytogenetic translocation t(15;17), which appeared following chemotherapy (ABVD), and radiotherapy for Hodgkin's disease (IIB). After treatment with all-trans retinoic acid (Vesanoid(R) 45 mg/m(2) daily) complete remission of t-APL was achieved. Then only one course of chemotherapy '3 + 7' (doxorubicin 45 mg/m(2) 1-3 d, cytosar 200 mg/m(2) 1-7d) was applied and the patient interrupted further treatment in July 1994, Four years later she had a normal pregnancy and delivered a healthy female infant in December 1998.